DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS

挥发性麻醉剂会调节苯二氮卓类药物与大脑神经元的结合吗

• 批准号: 6219243
• 负责人: LEONARD FIRESTONE
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219243
• 关键词: benzodiazepine receptor; benzodiazepines; drug interactions; drug receptors; human subject; isoflurane; midazolam; neurons; neuropharmacology; positron emission tomography; receptor binding

This protocol will use PET technology to determine if isoflurane anesthesia changes binding of 11C-flumazenil, a GABA agonist, to its receptor in different regions of the brain. Binding will be measured by the Bmax/KD quotient. This study will determine if isoflurane anesthesia changes the binding of the GABA antagonist midazolam in the interaction studies using combinations of 11C-flu-mazenil, unlabeled midazolam and isoflurane anesthesia.

该方案将使用PET技术来确定异氟烷麻醉是否会改变11 C-氟马西尼（一种GABA激动剂）与大脑不同区域中其受体的结合。 将通过Bmax/KD商测量结合。 本研究将确定异氟烷麻醉是否会改变11 C-流感-马西尼、未标记咪达唑仑和异氟烷麻醉联合给药的相互作用研究中GABA拮抗剂咪达唑仑的结合。