IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN

人脑中挥发性麻醉作用 5HT2A 受体的体内 PET 成像

• 批准号: 6219234
• 负责人: LEONARD FIRESTONE
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219234
• 关键词: anesthetics; bioimaging /biomedical imaging; clinical research; human subject; isoflurane; positron emission tomography; radiotracer; serotonin receptor

The mechanisms of volatile general anesthetics remain unclear. One of the putative targets for volatile general anesthetics is the brain serotonin receptor. This study will test the hypothesis that the 5HT2A receptor will not show a conformational change from anesthesia. The binding of the radiotracer 18F-altan-serin will be measured by PET in the presence of an anesthetizing concentration of isoflurane to that in isoflurane's absence will be compared.

挥发性全身麻醉药的作用机制尚不清楚。 挥发性全身麻醉药的假定靶点之一是脑5-羟色胺受体。 本研究将检验5 HT 2A受体不会因麻醉而显示构象变化的假设。 将在存在麻醉浓度的异氟烷的情况下通过PET测量放射性示踪剂18F-丙氨酸-丝氨酸的结合，并将在不存在异氟烷的情况下进行比较。