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IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN

IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN
人脑中挥发性麻醉作用 5HT2A 受体的体内 PET 成像
批准号：
6219234
负责人：
LEONARD FIRESTONE
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219234
关键词：
anesthetics bioimaging /biomedical imaging clinical research human subject isoflurane positron emission tomography radiotracer serotonin receptor

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中文摘要
翻译
挥发性全身麻醉药的作用机制尚不清楚。挥发性全身麻醉药的假定靶点之一是大脑中的5-羟色胺受体。这项研究将检验这一假设，即5HT2A受体在麻醉后不会显示构象变化。用PET测定18F-Altan-serin在异氟醚麻醉浓度和无麻醉浓度时的结合情况。
英文摘要
The mechanisms of volatile general anesthetics remain unclear. One of the putative targets for volatile general anesthetics is the brain serotonin receptor. This study will test the hypothesis that the 5HT2A receptor will not show a conformational change from anesthesia. The binding of the radiotracer 18F-altan-serin will be measured by PET in the presence of an anesthetizing concentration of isoflurane to that in isoflurane's absence will be compared.
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DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS
DO VOLATILE ANESTHETICS MODULATE BENZODIAZEPINE BINDING TO CEREBRAL NEURONS
IN VIVO PET IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN
IN VIVO IMAGING OF VOLATILE ANESTHETIC ACTION 5HT2A RECEPTOR IN HUMAN BRAIN