GENETIC ANALYSIS CASE STUDIES OF MAJOR PSYCHOTIC ILLNESS

重大精神疾病的基因分析案例研究

• 批准号: 6276571
• 负责人: MARILYN A DAVIES
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276571
• 关键词: bipolar depression; blood chemistry; clinical research; disease /disorder etiology; family genetics; genome; human subject; linkage mapping; molecular genetics; schizophrenia; statistics /biometry

The purpose of this project is to gather clinical and molecular genetic information from extended, highly informative families ascertained through well-diagnosed and well-characterized probands, in order to investigate, on a case to case basis, the role of genetics in the etiology of the major psychotic illness's. Specific Aims: 1) To systematically collect clinical and history data and blood samples for molecular genetic analysis. A sequential sampling design will be used to obtain the extended family information needed to address multiple hypotheses related to genetic etiology, anticipation and parent-of-origin effects. 2) To utilize clinical and laboratory data to search for evidence of susceptibility regions for bipolar disorder and schizophrenia. Linkage analysis will be utilized to assess previously implicated loci for possible confirmation, and to identify novel regions, both by consideration of candidate genes, and via a global genome search using a two-stage design. 3) To apply state of the art statistical genetic methods in order to assess genetic contributions to the complex etiology of bipolar disorder and schizophrenia, including possible anticipation and parent-of-origin effects.

该项目的目的是收集临床和分子遗传 来自扩展，信息丰富的家庭的信息确定 通过经过良好诊断且特征良好的概率，以便 在情况下，调查遗传学在案例中的作用 主要精神病的病因。 具体目的：1）系统收集临床和历史数据 和血液样本进行分子遗传分析。 顺序采样 设计将用于获取所需的扩展家庭信息 解决与遗传病因，预期有关的多种假设 和产卵的父母效应。 2）利用临床和实验室 搜索双极易感区域的证据 疾病和精神分裂症。 链接分析将用于评估 以前暗示的基因座以进行可能的确认，并确定 新的区域，无论是考虑候选基因还是通过 使用两个阶段设计的全球基因组搜索。 3）应用 艺术统计遗传学方法以评估遗传 对躁郁症和复杂病因的贡献 精神分裂症，包括可能的预期和父母。 效果。