GENETIC STUDY OF ATTENTION DEFICIT HYPERACTIVITY DISORDER

注意力缺陷多动障碍的遗传学研究

• 批准号: 6276566
• 负责人: MARILYN A DAVIES
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276566
• 关键词: attention deficit disorder; behavioral /social science research tag; behavioral genetics; catecholamines; child (0-11); clinical research; developmental neurobiology; family genetics; genetic disorder diagnosis; human subject; molecular genetics; phenotype

Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed psychiatric disorder of childhood. ADHD is characterized by inattention, hyperactivity, distractibility, nd other disruptive behaviors. Studies show that ADHD persists into adulthood in 10%-60% of childhood-onset cases with many dults showing high levels of comorbidity. In the majority of ADHD cases, no etiology has been determined. Discussions and research on the leading causes of ADHD focus on genetic factors, perinatal factors, infections and neurobiologic events. Studies over the past 30 years indicate that genetics is of etiological importance in this illness. Recent neurobiological findings and results from assoication studies suggest that genes associated with catecholamine mechanisms or neurodevelopmental processes may be involved in the etiology of ADHD. The herogeneity of ADHD suggests an etiology which could involve several different mutations at several loci or, alternatively, several genes could act together with each having a small effect. Given these parameters, it may be more dvantageous to rely on large samples of smaller, homogenous families rather than a heterogenous group of families or large pedigrees, both of which could obscure genetic mechanisms. This study will explore the genetic and molecular mechanisms involved in ADHD. the specific aims include: (1) case identification of probands with ADHD; (2) careful differential diagnosis after initial presentation with proper identification of comorbid conditions; (3) collectioin of a large sample of nuclear families who are well characterized ans subtyped by fmily history and phenotype definitions; (4) application of molecular genetic techniques to examine loci involved in catecholamine mechanisms and neuro- developmental processes related to attention systems.

注意缺陷多动症（ADHD）是最常见的 诊断为儿童精神障碍。 多动症的特征是 注意力不集中，多动症，分心，其他破坏性 行为。 研究表明，ADHD持续到成年10％-60％ 童年发作的案件，许多杜尔特都显示出高水平 合并症。 在大多数ADHD病例中，没有病因是 决定。 关于多动症主要原因的讨论和研究 专注于遗传因素，围产量因素，感染和 神经生物学事件。 过去30年的研究表明 遗传学在这种疾病中具有病因的重要性。 最近的 神经生物学发现和协同研究的结果表明 与儿茶酚胺机制或 神经发育过程可能与ADHD的病因有关。 多动症的悠久性表明一种病因，可能涉及几个 几个基因座或几个基因的不同突变 可以与每个效果相同。 鉴于这些 参数，依靠大型样本可能更为明显 较小的，同质的家族，而不是异质群 家庭或大家谱，两者都可能掩盖遗传 机制。 这项研究将探索遗传和分子 涉及多动症的机制。具体目的包括：（1）案例 用ADHD识别概率； （2）仔细的鉴别诊断 初始介绍后，并正确识别合并症 状况; （3）大量核心家庭的收集蛋白 由FMILY历史型和表型来表征ANS的特征 定义； （4）将分子遗传技术应用于 检查涉及儿茶酚胺机制和神经 - 与注意力系统有关的发展过程。