GENETIC INFLUENCES ON PSYCHIATRIC PATIENTS NICOTINE DEPENDENCE:ADDICT & DEPRESS

遗传对精神病患者尼古丁依赖的影响：成瘾

• 批准号: 6348137
• 负责人: MARILYN A DAVIES
• 金额: $ 0.38万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6348137
• 关键词: biomedical resource; clinical research; ethics; female; genetics; human subject; mental disorders; psychology; women's health

Investigators and clinicians at the Fragile X Clinic at Duke University Medical Center have observed the variable response to carrier testing of women of diverse ages, as well as the direct impact upon them and upon their immediate and extended families. In a recently completed pilot study of obligate carriers of Fragile X Syndrome, which attempted to ascertain opinions and attitudes regarding carrier testing, 89% of the respondents reported that prior knowledge of carrier status would have changed their reproductive plans. The study also solicited the opinion of respondents as to optimal timing of carrier testing and the optimal age to inform children of the heritable nature of the Fragile X Syndrome. The present study is designed to examine whether (1) the outcome of carrier testing is correlated with changes in self-concept, coping behavior, and family adaptation and support, (2) whether such variables as family adaptation and support, or self concept, can be used to help predict an individual's response to the outcome of carrier testing, and (3) whether women who are at risk differ from obligate carriers in their assessments of optimal age for learning of the heritable nature of Fragile X Syndrome, and for undergoing carrier testing. Specific problems encountered with carrier testing may well be more related to life stages than to chronological age.

杜克脆弱X诊所的研究人员和临床医生 大学医学中心已经观察到对 对不同年龄段的妇女的运营商测试以及直接影响 在他们以及他们的直系和大家庭上。 在 最近完成的脆弱载体X的试点研究X 综合征，试图确定意见和态度 关于运营商测试，有89％的受访者报告 对载体状态的了解将改变其生殖 计划。 这项研究还征求了受访者的意见 运营商测试的最佳时机和最佳年龄 脆弱X综合征的可遗传性质的孩子。 这 目前的研究旨在检查（1） 载体测试与自我概念的变化相关，应对 行为以及家庭的适应和支持，（2）是否这样 变量作为家庭的适应和支持，或自我概念，可以是 用于预测个人对结果的反应 运营商测试，以及（3）处于危险中的妇女是否不同于 在评估最佳年龄的学习中 脆弱X综合征的可遗传性质，用于经营载体 测试。 运营商测试遇到的具体问题可能很好 与生活阶段相比，与年龄更大。