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ANTITHROMBOTIC EFFECT OF ESCALATING DOSES OF PEG HIRUDIN IN HUMANS

ANTITHROMBOTIC EFFECT OF ESCALATING DOSES OF PEG HIRUDIN IN HUMANS
聚乙二醇水蛭素剂量递增对人体的抗血栓作用
批准号：
6276353
负责人：
JAMES H CHESEBRO
金额：
$6.67万
依托单位：
MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6276353
关键词：
cardiovascular disorder chemotherapy cardiovascular pharmacology clinical research coronary disorder dosage drug screening /evaluation hirudins human subject human therapy evaluation intravenous administration platelets thrombosis

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中文摘要
翻译
本建议的主要目的是测试剂量-抗血栓反应
英文摘要
The main aim of this proposal is to test the dose-antithrombotic response of escalating doses of intravenous hirudin in patients with chronic coronary or peripheral arterial disease. This aim will be tested by infusing escalating doses of intravenous PEG-hirudin and performing ex vivo perfusion studies of platelet-thrombus formation using blood from the antecubital vein of the patients.
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