EXERCISE AND GLUCOSE REGULATION IN AGING

年龄越大与糖耐量下降有关，而糖耐量下降本身 是非胰岛素依赖型糖尿病发生的重要先兆 糖尿病(NIDDM)和随后的心血管疾病(CVD)。我们建议 葡萄糖耐量随年龄的下降是可以解释的， 在很大程度上，由于随之而来的体能下降 活动。因此，拟议研究的总体目的是 确定有氧运动对改善血糖的影响 对老年人的监管。 到目前为止，我们已经确定了钳夹程序的可靠性 3名较年轻的受试者和2名年龄较大的受试者。此外，我们还测试了 单次运动(最高75-80%)12小时或以下的急性影响 8例受试者24小时血糖处理。

Older age is associated with a decline in glucose tolerance which itself is an important precursor to the development of non-insulin-dependent mellitus (NIDDM) and subsequent cardiovascular disease (CVD). We propose that the decline in glucose tolerance with aging can be accounted for, to a significant extent, by the concomitant decline in physical activity. Thus, the overall purpose of the proposed study is to determine the impact of aerobic exercise on improvements in glucose regulation in older people. To date we have established the reliability of the clamp procedure on 3 younger subjects and 2 older subjects. In addition we have tested the acute effects of a single bout of exercise (75-80% max) on 12 hour or 24 hour glucose disposal in 8 subjects.