STIMULATION OF IMMUNITY AGAINST RETROVIRAL ENVELOPE PROTEINS: SAIDS: VACCINE

目的：探讨一种转基因生物的抗病能力。 刺激黏膜和体液免疫的细菌载体 猴免疫缺陷病毒的包膜蛋白。结果A 表达p27基因的重组鼠伤寒沙门氏菌 测试以确定它是否会刺激免疫记忆和 促进针对包膜蛋白的抗体反应。肠道暴露 对这株S.T.来说。足以增强免疫力，也 论证了粘膜与胃粘膜之间的重要关系 体液免疫隔膜。未来的方向已经确定 这种细菌载体能激发免疫记忆对抗 包膜蛋白很重要的一点是确定这是否 疫苗策略足以促进保护性免疫。在……里面 此外，重要的是要验证衰减过程 是稳定的，而且细菌在肠道中不容易变异 环境。关键词类固醇激素、粘膜免疫、沙门氏菌 鼠伤寒杆菌疫苗

OBJECTIVE: To investigate to ability of a genetically altered bacterial vector to stimulate mucosal and humoral immunity against envelope proteins of simian immunodeficiency virus. RESULTS A recombinant strain of Salmonella typhimurium that expresses p27 was tested to determine if it would stimulate immunological memory and facilitate antibody responses against envelope proteins. Gut exposure to this strain of S.t. was sufficient to augment immunity, also demonstrating the important relationship beween the mucosal and humoral immune compartments. FUTURE DIRECTIONS Having established that this bacterial vector elicits immunological memory against envelope proteins it would be important to determine whether this vaccine strategy is sufficient to promote protective immunity. In addition, it will be important to verify that the attenuation process is stable and that the bacteria is not prone to mutate in the gut environment. KEY WORDS SAIDS, mucosal immunity, Salmonella typhimurium, vaccine