QUINOLINIC ACID AS BIOMARKER OF SIV INFECTION & SAIDS: CNS

喹啉酸作为 SIV 感染的生物标志物

• 批准号: 6277649
• 负责人: CHRISTOPHER L COE
• 金额: $ 10.51万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277649
• 关键词: AIDS; Mammalia; Primates; immunology; infection; inflammation; lymphatic system; virus

OBJECTIVE: To evaluate changes in quinolinic acid production in response to viral infection and disease progression. RESULTS Previously we demonstrated that the neurotoxin, quinolinic acid, is increased in both systemic circulation and the intrathecal compartment following retroviral infection. We have now begun to investigate the potential sources of QUIN within the CNS. QUIN within the CNS may derive from diffusion across the blood-brain-barrier or may reflect endogenous production with the CNS by cells related to the monocyte/macrophage lineage. Previously collected, frozen postmortem tissue samples from infected animals are being analyzed to determine the regional distribution of QUIN within the brain. FUTURE DIRECTIONS One future direction would be to test the effectiveness of NMDA receptor antagonists in blocking the adverse effects of QUIN on neural tissue. KEY WORDS quinolinic acid, blood-brain-barrier, simian immunodeficiency virus, cerebrospinal fluid NIMH MH41659

目的：评价在不同的条件下， 对病毒感染和疾病进展的反应。 结果 以前我们证明，神经毒素，喹啉酸， 体循环和鞘内室均增加 逆转录病毒感染后。 我们现在开始调查 CNS内QUIN的潜在来源。 CNS内的QUIN可以 来源于穿过血脑屏障的扩散，或可能反映 内源性生产与中枢神经系统相关的细胞 单核细胞/巨噬细胞谱系。 先前采集，死后冷冻 从受感染动物身上采集的组织样本正在进行分析， QUIN在大脑中的区域分布。 未来方向 未来的一个方向是测试NMDA的有效性 受体拮抗剂阻断QUIN对神经元的不良作用 组织. 关键词喹啉酸，血脑屏障，猿猴 脑脊液免疫缺陷病毒