MANGANESE & INFANT FORMULA ON MANGANESE & IRON STATUS OF INFANTS

婴儿配方奶粉含有相当高的 锰的浓度高于母乳。 因为身材很高 锰的负担可能有毒性作用，重要的是要研究 锰是如何从各种类型的公式吸收，以及如何 婴儿的锰状况受到影响。 此外，由于锰和 铁竞争吸收，重要的是要评估的影响， 高锰摄入对血液学和铁状况的影响。 目的 含有不同水平的 锰（35-200微克/升），从出生到6个月大的幼猴 年龄，并研究其对生长、锰吸收和 状态，以及对血液学、铁吸收和状态的影响。 结果锰和铁的吸收明显低于对照组， 锰含量最高的配方奶粉（大豆配方奶粉）， 所有其他配方奶粉在6周龄时。 然而，在3个月大的时候， 两组之间没有差异，这表明身体 锰的负荷不影响锰的保留。 全血 锰反映了锰的摄入量， 公式具有最高的锰水平，而血清铁蛋白是 在这一组中更低。 今后的方向为了评价 锰在体内的各种生理水平的增加 功能协调发展的 关键词锰，锰吸收，铁，铁 婴儿营养状况

Significance Infant formulas contain considerable higher concentrations of manganese than human milk. Since very high body burdens of manganese may have toxic effects, it is important to study how well manganese is absorbed from various types of formula and how manganese status of infants is affected. Further, as manganese and iron compete for absorption, it is important to assess the effect of high manganese intake on hematology and iron status. Objectives To feed milk-based and soy-based infant formulas with different levels of manganese (35-200 ug/L) to infant monkeys from birth to 6 months of age and to study the effects on growth, manganese absorption and status, and the effects on hematology, iron absorption and status. Results Manganese and iron absorption was significantly lower from the formula with the highest level of manganese (soy formula) than from all other formulas at 6 weeks of age. At 3 months of age, however, there was no difference between the groups, suggesting that body burden of manganese does not affect manganese retention. Whole blood manganese reflected manganese intake and was highest in the group fed formula with the highest manganese level, while serum ferritin was lower in this group. Future Directions To evaluate the effect of increased levels of manganese in the body on various physiological functions. KEYWORDS manganese, manganese absorption, iron, iron status, infant nutrition