SHORT TERM EFFECT OF MILK PROTEIN DIGESTIBILITY IN RHESUS MONKEYS

乳蛋白消化率对恒河猴的短期影响

• 批准号: 3742122
• 负责人: BO LONNERDAL
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742122
• 关键词: Macaca mulatta; gastrointestinal absorption /transport; milk; nutrition related tag; protein metabolism

Various cow milk proteins are used in formulas intended for human infants. However, it is difficult to evaluate which combination of proteins is optimal and also the possible effect of their heat treatment on infant nutrition. The amino acid composition of the proteins does not give adequate information as digestibility of the proteins will determine the extent to which amino acids will be absorbed by the infant. The digestibility will also be affected by the age of the infant. For human infants, the post-prandial amino acid pattern has been shown to reflect protein composition and quality. In this study we used nursing infant rhesus monkeys to evaluate this method. The monkeys were given infant formula based on 6 different protein sources by orogastric intubation. Blood samples were drawn by an in-dwelling catheter at different times post-feeding. Plasma samples were analyzed for free amino acids and blood urea nitrogen (bun). The results show that there is a post-prandial rise and subsequent decline in plasma amino acids and that this varies among the amino acids. Inter-individual variations in response among the infants were relatively large, however, making this assessment difficult in a limited number of animals. Bun values were more consistent among animals and may be used as an indicator of protein digestibility in infants.

各种牛奶蛋白质用于人类配方中， 婴儿。 然而，很难评估哪种组合 蛋白质是最佳的，也可能影响他们的热处理 关于婴儿营养。 蛋白质的氨基酸组成不 提供足够的信息，因为蛋白质的消化率将决定 氨基酸被婴儿吸收的程度。 的 消化率也会受到婴儿年龄的影响。 人类 婴儿，餐后氨基酸模式已被证明反映了 蛋白质组成和质量。 在这项研究中，我们使用了护理婴儿 恒河猴来评估这种方法。 这些猴子被给予婴儿 基于6种不同蛋白质来源的配方。 在不同时间用留置导管抽取血样 喂食后。 分析血浆样品的游离氨基酸和 血尿素氮（BUN）。 结果表明， 餐后升高和随后的血浆氨基酸下降， 这在氨基酸中是不同的。 的个体间差异 然而，婴儿的反应相对较大， 在有限数量的动物中难以评估。 Bun值 在动物中更一致，可用作蛋白质的指示剂 婴儿的消化率。