BIOACTIVITY & NUTRITIONAL QUALITY OF MILK PROTEIN FRACTIONS

生物活性

• 批准号: 6116728
• 负责人: BO LONNERDAL
• 金额: $ 4.41万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116728
• 关键词: Mammalia; bacteria; communicable diseases; growth /development; hematology; mother /infant health care; nutrition; nutrition related tag

Significance Epidemiologically, breast-fed infants contract fewer infections and have infections of shorter duration. These differences may be due to differences in composition between breast milk and formula. Glycomacropeptide, (GMP, a highly negatively charged carbohydrate found in milk) may mimic the glycans that bacteria use for attachment in the small intestine and thus may inhibit attachment and colonization, thereby preventing infections. Alpha-lactalbumin, (ALA, a predominant milk protein) is believed to make a major contribution to the balanced plasma amino acid pattern of breast-fed infants and may aid in the absorption of calcium and zinc. The effects of GMP or ALA supplementation will be assessed by the capacity to respond to a microbial challenge as well as by tracing mineral and amino status. Objectives To study the effects of glycomacropeptide (GMP) and alpha-lactalbumin (ALA) on the colonization of pathogenic bacteria as well as anthropometry, hematology and indices of mineral nutriture in infant monkeys. Results Although no differences in length were observed, a significant differences in weight between animals fed GMP and breast-fed infants was found. GMP and ALA resulted in significant increases in serum zinc as 2, 3, 4 and 5 months of age. The absorption of zinc was higher in the animals receiving ALA or GMP as compared with breast-fed infants. Although there were no differences in thymus size, animals receiving ALA or breast milk responded differently to inoculation of E. coli as assessed by changes in differential white blood cell count. Future Directions To evaluate the effect of other milk protein fractions on various pathogens. KEY WORDS glycomacropeptide, alpha-lactalbumin, E. coli, pathogens, prebiotic, infant nutrition FUNDING Private Sector

流行病学意义：母乳喂养的婴儿感染较少 感染，且感染持续时间较短。这些差异 可能是由于母乳和乳汁的成分不同 配方。糖巨肽，(GMP，一种带高度负电荷的 牛奶中发现的碳水化合物)可能模仿细菌使用的多糖 用于在小肠中附着，因此可能会抑制附着 和移民化，从而防止感染。α-乳清蛋白， (ALA，一种主要的牛奶蛋白质)被认为是一种主要的 母乳喂养对平衡血浆氨基酸模式的贡献 对婴儿有益，有助于钙和锌的吸收。这个 GMP或ALA的补充效果将根据容量进行评估 为了应对微生物的挑战，以及通过追踪矿物和 氨基状态。目的研究糖巨肽的作用机制。 乳清蛋白(GMP)和α-乳清蛋白(ALA)对致病菌定植的影响 细菌以及人体测量学、血液学和矿物质指数 幼猴体内的营养物质。结果虽然没有任何差异 体长均观察到，体重有显著差异 喂养GMP的动物和母乳喂养的婴儿被发现。GMP和ALA 导致血清锌显著升高，如2，3，4和5 几个月大的孩子。动物对锌的吸收较高。 与母乳喂养的婴儿相比，接受ALA或GMP的婴儿。虽然 在接受ALA或ALA的动物的胸腺大小方面没有差异 母乳对接种大肠杆菌AS的反应不同 通过白细胞分类计数的变化进行评估。未来 评价其他牛奶蛋白质组分对 各种病原体。关键词糖巨肽、α-乳清蛋白、E. 大肠杆菌、病原体、益生菌、婴儿营养资助私营部门