ANTIMICROBIAL & ANTI INFLAMMATORY EFFECTS OF LACTOFERRIN

流行病学意义：母乳喂养的婴儿感染较少 感染，且感染持续时间较短。这些差异 可能归因于母乳成分的差异 和配方奶粉。乳铁蛋白(人体内发现的一种金属螯合糖蛋白 和灵长类牛奶)也被认为具有抗菌活性 具有抗内毒素引起的炎症作用。另外， 乳铁蛋白可能通过以下途径间接抑制病原性定植 鼓励创造更适合更多人成长的环境 “对宿主友好”的细菌。因此牛奶中乳铁蛋白的存在 可能在一定程度上解释了母乳喂养婴儿的承受能力 感染。因此，婴儿配方奶粉的补充 乳铁蛋白可能有助于保护配方奶婴儿免受微生物的影响 感染。目的在婴幼儿配方奶粉中添加 用乳铁蛋白，给他们接种一种大肠杆菌，并评估 它们抵抗感染和重新定植肠道的能力 双歧杆菌和乳杆菌。结果小鼠肠道菌群 母乳喂养的猴子与配方奶喂养的猴子的不同之处在于 配方奶喂养的猴子有优势的大肠杆菌和母乳喂养 猴子有优势的乳杆菌。另外， 乳铁蛋白似乎可以防止大肠杆菌定植的增加 同时用双歧杆菌或 乳酸菌。其他影响评估的未来方向 各种病原体上的益生菌。关键词乳铁蛋白、大肠杆菌、 病原体、益生菌、婴儿营养资助私营部门

Significance Epidemiologically, breast-fed infants contract fewer infections and have infections of shorter duration. These differences may be attributed to differences in composition between breast milk and formula. Lactoferrin (a metal chelate glycoprotein found in human and primate milk) is known to possess antimicrobial activity as well as act against endotoxin induced inflammation. Additionally, lactoferrin may indirectly suppress pathogenic colonization by encouraging an environment more suitable for growth of more "host-friendly" bacteria. Thus the presence of lactoferrin in milk may account, in part, for the breast-fed infant's ability to withstand infection. Therefore, supplementation of infant formula with lactoferrin may help protect formula-fed infants from microbiologic infection. Objectives To feed infant monkeys formula supplemented with lactoferrin, inoculate them with a strain of E. coli and assess their ability to resist the infection and recolonize the intestine with Bifidobacteria and Lactobacilli. Results The intestinal flora of breast-fed monkeys differs from that of formula-fed monkeys in that formula-fed monkeys have a predominance of E. coli and breast-fed monkeys have a predominance of Lactobacilli. Additionally, lactoferrin seemed to prevent an increase in E. coli colonization while stimulating the colonization with Bifidobacteria or Lactobacilli. Future Directions To evaluate the effects of other prebiotics on various pathogens. KEY WORDS lactoferrin, E. coli, pathogens, prebiotic, infant nutrition FUNDING Private Sector