ANTIMICROBIAL & ANTI INFLAMMATORY EFFECTS OF LACTOFERRIN

抗菌剂

• 批准号: 6116727
• 负责人: BO LONNERDAL
• 金额: $ 4.41万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116727
• 关键词: Mammalia; bacteria; communicable diseases; mother /infant health care; nutrition; nutrition related tag

Significance Epidemiologically, breast-fed infants contract fewer infections and have infections of shorter duration. These differences may be attributed to differences in composition between breast milk and formula. Lactoferrin (a metal chelate glycoprotein found in human and primate milk) is known to possess antimicrobial activity as well as act against endotoxin induced inflammation. Additionally, lactoferrin may indirectly suppress pathogenic colonization by encouraging an environment more suitable for growth of more "host-friendly" bacteria. Thus the presence of lactoferrin in milk may account, in part, for the breast-fed infant's ability to withstand infection. Therefore, supplementation of infant formula with lactoferrin may help protect formula-fed infants from microbiologic infection. Objectives To feed infant monkeys formula supplemented with lactoferrin, inoculate them with a strain of E. coli and assess their ability to resist the infection and recolonize the intestine with Bifidobacteria and Lactobacilli. Results The intestinal flora of breast-fed monkeys differs from that of formula-fed monkeys in that formula-fed monkeys have a predominance of E. coli and breast-fed monkeys have a predominance of Lactobacilli. Additionally, lactoferrin seemed to prevent an increase in E. coli colonization while stimulating the colonization with Bifidobacteria or Lactobacilli. Future Directions To evaluate the effects of other prebiotics on various pathogens. KEY WORDS lactoferrin, E. coli, pathogens, prebiotic, infant nutrition FUNDING Private Sector

从流行病学的角度来看，母乳喂养的婴儿 感染和感染的持续时间较短。 这些差异 这可能是由于母乳中的成分不同， 和公式。 乳铁蛋白（一种在人体内发现的金属螯合糖蛋白） 和灵长类动物乳）也具有抗微生物活性 作为对抗内毒素诱导的炎症的作用。 此外，本发明还 乳铁蛋白可以通过以下方式间接抑制病原体定植： 鼓励创造更适合发展的环境， "宿主友好型"细菌 因此，牛奶中的乳铁蛋白 可能部分解释了母乳喂养的婴儿 感染 因此，在婴儿配方食品中添加 乳铁蛋白可能有助于保护配方奶粉喂养婴儿免受微生物 感染 目的给幼猴配方奶粉中添加 与乳铁蛋白结合，再用大肠杆菌菌株大肠杆菌，并评估 他们抵抗感染和消化肠道的能力 双歧杆菌和乳酸杆菌。 结果肠道植物群 母乳喂养的猴子与配方奶喂养的猴子的区别在于， 配方奶喂养的猴子中E.大肠杆菌和母乳喂养 猴子的乳酸杆菌占优势。 此外，本发明还 乳铁蛋白似乎阻止了E.大肠杆菌定殖 同时刺激双歧杆菌的定殖， 乳酸杆菌。 今后的方向评价其他影响 益生元对各种病原体的作用。 关键词乳铁蛋白，E.大肠杆菌， 病原体、益生元、婴儿营养资助私营部门