ALDOSE REDUCTASE GENE EXPRESSION IN HISPANICS

西班牙裔人的醛糖还原酶基因表达

• 批准号: 6279754
• 负责人: PHILIP George ZAGER
• 金额: $ 2.62万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279754
• 关键词: Hispanic Americans; aldehyde reductase; caucasian American; chronic renal failure; clinical research; diabetes mellitus genetics; diabetic nephropathy; gene expression; genetic polymorphism; human genetic material tag; human subject; noninsulin dependent diabetes mellitus; racial /ethnic difference

Diabetes is the leading cause of end stage renal disease in the USA. ESRD demonstrates higher rate amongst minority groups. We postulate that genetic mechanisms increase the relative risk of type 2 diabetes related ESRD in Hispanics compared to non-Hispanic whites. The object of this preliminary project is to conduct a preliminary cross sectional study to explore the hypothesis that there is heterogeneity in Aldose Reductase 2 (AALR2) gene expression.

在美国，糖尿病是导致终末期肾病的主要原因。ESRD