MECHANISM OF INSULIN AND IGF-1 ACTION ON SKELETAL MUSCLE BLOOD FLOW

胰岛素和 IGF-1 对骨骼肌血流的作用机制

• 批准号: 6279385
• 负责人: EUGENE Joseph BARRETT
• 金额: $ 3.19万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279385
• 关键词: angiogenesis; capillary bed; clinical research; human subject; insulin; insulinlike growth factor; noninsulin dependent diabetes mellitus; obesity; striated muscles

Over the past 4 years, considerable data has indicated that insulin increases skeletal muscle blood flow in healthy humans and insulin- resistance in NIDDM and obese skeletal muscle is accompanied by a diminished vascular response. It is not known whether the increase in muscle blood flow is due to enhanced flow to previously perfused muscle or to recruitment of new capillary beds. Using two techniques developed in our laboratories, we will test the hypothesis that insulin and IGF-I act to open new capillary beds. These studies are ongoing. Preliminary results indicate that insulin not only induces this changes in total skeletal muscle blood flow, but also recruits new capillary elements thus affecting blood flow distribution within muscle. Future experiments will take advantage of albumin coated microbubbles that can be injected intravenously rather than interarterially.

在过去的四年里，大量的数据表明，胰岛素 增加健康人的骨骼肌血流量和胰岛素- NIDDM和肥胖骨骼肌的耐药性伴随着 血管反应减弱。目前尚不清楚是否会增加 肌肉血流量是由于增强了对先前灌流的肌肉的流动。 或招募新的毛细管床。使用开发的两种技术 在我们的实验室里，我们将测试胰岛素和IGF-I的假设 行动起来，开辟新的毛细管床。这些研究正在进行中。初步 结果表明，胰岛素不仅在总体上导致了这种变化。 骨骼肌血液流动，还招募新的毛细血管元素 从而影响肌肉内的血流分布。未来 实验将利用白蛋白包裹的微泡，可以 静脉注射而不是动脉间注射。