STRUCTURE OF THE INSULIN RECEPTOR AND IRS 1 GENES

胰岛素受体和 IRS 1 基因的结构

• 批准号: 6279901
• 负责人: Jeffrey S Flier
• 金额: $ 2.49万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279901
• 关键词: clinical research; diabetes mellitus genetics; female; genetic mapping; human subject; insulin receptor; insulin sensitivity /resistance; polycystic ovary syndrome; protein structure function; receptor expression

The goals of this study are to determine the biochemical function of the insulin receptor and IRS-1 in vitro and in vivo action in female patients with Type A syndrome of insulin resistance and to determine the sequence of the coding regions of the insulin receptor and IRS-1 genes in non-obese individuals with PCO having insulin resistance.

本研究的目的是确定的生化功能， 女性患者胰岛素受体和IRS-1体内外作用 A型胰岛素抵抗综合征的患者，并确定 胰岛素受体和IRS-1基因编码区的非肥胖 患有PCO的个体具有胰岛素抵抗。