LOW SPIN FERRIC PROTEIN MODELS

低自旋铁蛋白模型

• 批准号: 6120391
• 负责人: ROBERT C SCARROW
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120391
• 关键词: biological products; biomedical resource; enzymes; spectrometry

We have also obtained EXAFS data on model low spin ferric compounds prepared by Henry Jackson and Prof. Julia Kovacs of the Department of Chemistry, University of Washington. These complexes have a ligand with a N3S2 donor set and can be prepared as a binary low spin iron (III) complex (a rare example of five-coordinate iron (III) or as ternary, six-coordinate complexes with a variety of auxilliary ligands including azide and nitric oxide. The EXAFS and edge intensities of these complexes are being compared to those of nitrile hydratase to gain further insight into the coordination of iron in the enzyme.

我们还获得了模型低自旋铁的EXAFS数据 化合物由亨利杰克逊和朱莉娅科瓦奇教授制备， 华盛顿大学化学系。 这些复合物 具有带有N3S2供体组的配体，并且可以制备为二元 低自旋铁（III）配合物（五配位铁的罕见例子 (III)或作为三元六配位络合物与多种 辅助配体包括叠氮化物和一氧化氮。 EXAFS和 这些复合物的边缘强度与 腈水合酶，以进一步了解 酶中的铁