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PATCH CAPACITANCE RECORDING OF RBL CELLS DURING SECRETION

PATCH CAPACITANCE RECORDING OF RBL CELLS DURING SECRETION
RBL 细胞分泌期间的贴片电容记录
批准号：
6121875
负责人：
RUSSELL THOMPSON
金额：
$8.32万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6121875
关键词：
animal tissue bioengineering /biomedical engineering biomedical resource human tissue immunology inflammation lipids lymphatic system

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英文摘要
A patch clamp capacitance recording system has been set up with a resolution of 0.1 fF, allowing high resolution measurements of secretion in the patch. We have applied this system to RBL cells, a cell line commonly used for studying secretion. While we have seen endocytosis (downward steps in capacitance), no exocytotic steps have been observed during secretion. Instead, we see spikes in the capacitance, possibly indicating transient fusion events where the vesicle fuses only briefly with the plasma membrane. Work is underway to confirm the nature of the capacitance spikes and explore their dependence on external calcium and other conditions necessary for secretion
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