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PROTEASE INVOLVED IN DNA BINDING

PROTEASE INVOLVED IN DNA BINDING
参与 DNA 结合的蛋白酶
批准号：
6281353
负责人：
Walter F. Mangel
金额：
$0.37万
依托单位：
BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-04-01 至 1999-03-31
来源：
https://reporter.nih.gov/project-details/6281353
关键词：
animal tissue biomedical resource growth /development infection vaccines virus

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英文摘要
An adenovirus protease is known to bind to double stranded DNA, and it is believed to put a bend into it. The protein is small (only 211 amino acids) so is unlikely to look like much in the STEM. In a preliminary experiment, a 300 bp piece of DNA with the protein bound was examined to see if the DNA was "kinked". Somehow, there was too little DNA present, so the experiment will be repeated. The proteinase activity is modified by DNA and protein cofactors. A cysteine on the protemase was Au-labeled. The hope is to look at it in the STEM in conjunction with different cofactors to locate the proteinase in the complex.
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Maturation of adenovirus via a new type of biochemistry
MECHANISM OF CATALYSIS OF THE ADENOVIRUS PROTEINASE- NEW TARGETS FOR ANTIVIRAL T
MOLECULAR DYNAMICS SIMULATIONS OF THE ACTIVATION OF THE ADENOVIRUS PROTEINASE B
  • 批准号：
    8364255
  • 项目类别：
  • 资助金额：
    $0.11万
  • 财政年份：
    2011
  • 负责人：
    Walter F. Mangel
  • 依托单位：
    CARNEGIE-MELLON UNIVERSITY
MOLECULAR DYNAMICS SIMULATIONS OF THE ACTIVATION OF THE ADENOVIRUS PROTEINASE B
  • 批准号：
    7723156
  • 项目类别：
  • 资助金额：
    $0.05万
  • 财政年份：
    2008
  • 负责人：
    Walter F. Mangel
  • 依托单位：
    CARNEGIE-MELLON UNIVERSITY
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