BIODEMOGRAPHIC ANALYSIS OF AGING TRAJECTORIES

衰老轨迹的生物人口学分析

• 批准号: 2371765
• 负责人: SHIRO HORIUCHI
• 金额: $ 7.53万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2371765
• 关键词: aging; animal data; animal morbidity; animal mortality; animal old age; animal population study; gender difference; genetic susceptibility; high risk behavior /lifestyle; human data; human morbidity; human mortality; human population study; mathematical model; racial /ethnic difference; smoking; species difference; statistics /biometry; vital statistics

Age trajectories of total and cause-specific mortality, morbidity, and disability as well as those of biomarkers are fundamental data in aging research. Patterns and differentials of these age trajectories reflect the mechanisms of senescence, evolutionary backgrounds of the mechanisms, relationships between senescence and diseases, and environmental and genetic effects on senescence. In order to analyze the age trajectories in more depth than in previous studies and detect clues about the underlying senescent processes, innovative quantitative approaches need to be developed. Thus statistical demographers experienced in age variation analysis have high potentials to make important contributions to biomedical gerontology. The background of the candidate, Shiro Horiuchi, is formal and mathematical demography. This proposal seeks funds for him to develop his career as an independent scientist in the biodemography of aging, by conducting the proposed research, strengthening this biomedical background, and broadening his collaborative network with biomedical investigators. His environment is highly suitable for his career development: the Rockefeller University is known for high quality in biomedical research and cooperates closely in training and research with Cornell University Medical College and Memorial Sloan Kettering Institute; and the Laboratory of Populations at RU pursues quantitative approaches to biomedical problems. (Since his research is statistical data analysis, other sources of research support will not necessarily be needed.) Horiuchi's recent studies have underscored the importance of age variations in the rate of senescence progression. In the proposed research, he will (a) compare patterns of the rate of relative mortality increase with age (life table aging rate, or LAR) among various species; (b) examine if environmental and genetic risk factors (in particular, smoking and high-fat diet) not only raise the overall levels of total and cause-specific mortality but also accelerate their age-related increases; (c) investigate senescence-rooted interdependence among major causes of death by examining interrelationships among LAR patterns of degenerative diseases; (d) analyze aging rate patterns of morbidity, disability, and biomarkers with emphasis on dementia-related variables; and compare differential aging rate profiles by race/sex categories.

总死亡率和特定原因死亡率、发病率和死亡率的年龄轨迹 残疾以及生物标志物是衰老的基本数据 研究。 这些年龄轨迹的模式和差异反映了 衰老机制、进化背景 衰老与疾病之间的机制、关系，以及 环境和遗传对衰老的影响。 为了分析 比以前的研究更深入地研究年龄轨迹并检测 有关潜在衰老过程的线索，创新的定量方法 需要制定一些方法。 因此统计人口统计学家 具有年龄变异分析经验的人具有很高的潜力 对生物医学老年学做出了重要贡献。 候选人堀内四郎出身正式， 数学人口统计学。 该提案为他寻求资金来发展 他作为衰老生物人口学独立科学家的职业生涯， 通过进行拟议的研究，加强这种生物医学 背景，并扩大他与生物医学的合作网络 调查人员。 他的环境非常适合他的职业 发展：洛克菲勒大学以其高品质而闻名 生物医学研究，并在培训和研究方面密切合作 康奈尔大学医学院和纪念斯隆凯特琳学院 研究所; RU 人口实验室致力于定量研究 解决生物医学问题的方法。 （由于他的研究是统计性的 数据分析，其他来源的研究支持不一定会 被需要。） 堀内最近的研究强调了年龄的重要性 衰老进展速度的变化。 在提议的 研究中，他将 (a) 比较相对死亡率的模式 不同物种之间随着年龄的增长（生命表老化率，LAR）而增加； (b) 检查环境和遗传风险因素（特别是， 吸烟和高脂肪饮食）不仅提高了总体水平 和特定原因死亡率，但也加速了与年龄相关的死亡率 增加； (c) 研究主要疾病之间因衰老而产生的相互依赖性 通过检查 LAR 模式之间的相互关系来确定死亡原因 退行性疾病； (d) 分析发病率的老化率模式， 残疾和生物标志物，重点关注痴呆相关变量； 并按种族/性别类别比较不同的老化率概况。