BIODEMOGRAPHIC ANALYSIS OF AGING TRAJECTORIES

衰老轨迹的生物人口学分析

• 批准号: 6509354
• 负责人: SHIRO HORIUCHI
• 金额: $ 11.04万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509354
• 关键词: aging; animal data; animal morbidity; animal mortality; animal old age; animal population study; gender difference; genetic susceptibility; high risk behavior /lifestyle; human data; human morbidity; human mortality; human population study; mathematical model; racial /ethnic difference; smoking; species difference; statistics /biometry; vital statistics

Age trajectories of total and cause-specific mortality, morbidity, and disability as well as those of biomarkers are fundamental data in aging research. Patterns and differentials of these age trajectories reflect the mechanisms of senescence, evolutionary backgrounds of the mechanisms, relationships between senescence and diseases, and environmental and genetic effects on senescence. In order to analyze the age trajectories in more depth than in previous studies and detect clues about the underlying senescent processes, innovative quantitative approaches need to be developed. Thus statistical demographers experienced in age variation analysis have high potentials to make important contributions to biomedical gerontology. The background of the candidate, Shiro Horiuchi, is formal and mathematical demography. This proposal seeks funds for him to develop his career as an independent scientist in the biodemography of aging, by conducting the proposed research, strengthening this biomedical background, and broadening his collaborative network with biomedical investigators. His environment is highly suitable for his career development: the Rockefeller University is known for high quality in biomedical research and cooperates closely in training and research with Cornell University Medical College and Memorial Sloan Kettering Institute; and the Laboratory of Populations at RU pursues quantitative approaches to biomedical problems. (Since his research is statistical data analysis, other sources of research support will not necessarily be needed.) Horiuchi's recent studies have underscored the importance of age variations in the rate of senescence progression. In the proposed research, he will (a) compare patterns of the rate of relative mortality increase with age (life table aging rate, or LAR) among various species; (b) examine if environmental and genetic risk factors (in particular, smoking and high-fat diet) not only raise the overall levels of total and cause-specific mortality but also accelerate their age-related increases; (c) investigate senescence-rooted interdependence among major causes of death by examining interrelationships among LAR patterns of degenerative diseases; (d) analyze aging rate patterns of morbidity, disability, and biomarkers with emphasis on dementia-related variables; and compare differential aging rate profiles by race/sex categories.

总死亡率、发病率和死因特异性死亡率的年龄轨迹 残疾以及生物标志物是衰老的基本数据 research. 这些年龄轨迹的模式和差异反映了 衰老的机制，进化背景， 机制，衰老和疾病之间的关系，以及 环境和遗传对衰老的影响。 为了分析 年龄轨迹比以前的研究更深入， 关于潜在衰老过程的线索，创新的定量 需要制定办法。 因此统计人口学家 有年龄变异分析经验的人有很高的潜力， 对生物医学老年学的重要贡献。 候选人堀内四郎的背景是正式的， 数学人口学 这一提议为他寻求资金， 他作为一名独立科学家的职业生涯， 通过开展拟议的研究，加强这一生物医学 背景，并扩大他的合作网络与生物医学 investigators. 他的环境非常适合他的职业 发展：洛克菲勒大学以高质量而闻名， 生物医学研究，并在培训和研究方面与 康奈尔大学医学院和斯隆凯特琳纪念医院 研究所;和人口在RU实验室追求定量 解决生物医学问题。 （因为他的研究是统计学的。 数据分析，其他研究支持来源不一定 需要）。 堀内最近的研究强调了年龄的重要性 衰老进展速度的变化。 拟议 研究，他将（a）比较相对死亡率的模式 在不同物种中随年龄增加（生命表老化率，或LAR）; (b)检查环境和遗传风险因素（特别是， 吸烟和高脂肪饮食）不仅提高了总的总体水平 和原因特异性死亡率，但也加速了他们与年龄相关的 （c）调查各主要组织之间根深蒂固的相互依存关系 通过检查LAR模式之间的相互关系， 退化性疾病;（d）分析发病率的老化率模式， 残疾和生物标志物，重点是痴呆相关变量; 并按种族/性别类别比较不同的老化率曲线。

项目成果

Differential patterns of age-related mortality increase in middle age and old age.

中年和老年与年龄相关的死亡率增加的不同模式。

• DOI: 10.1093/gerona/58.6.b495
• 发表时间: 2003
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Horiuchi,Shiro;Finch,CalebE;Meslé,France;Vallin,Jacques
• 通讯作者: Vallin,Jacques