EFFECT OF TAMOXIFEN ON THE REGULATION OF IL 1 IN MONOCYTE CULTURE

他莫昔芬对单核细胞培养中IL-1的调节作用

• 批准号: 6282248
• 负责人: GLORIA RICHARD-DAVIS
• 金额: $ 1.97万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282248
• 关键词: bone metabolism; clinical trials; cytokine; estrogens; hormone regulation /control mechanism; human subject; interleukin 1; monocyte; tamoxifen; tissue /cell culture

Tamoxifen, a nonsteroidal antiestrogen drug, is used in the treatment of breast cancer. With its antiestrogen properties, it binds to estrogen receptors thus blocking estrogen dependent tumor growth. Estrogen, mainly the lack of, is instrumental in the cause of osteoporosis. At menopause, the lack of estrogen causes an increase in bone loss. Tamoxifen in a hypoestrogenic environment, post menopause, appears to have estrogen like effects and inhibits bone resorption. In vitro studies, however, demonstrate that Tamoxifen in the presence of estrogen actually inhibits the beneficial effects of estrogen on bone metabolism. This study will help to evaluate the beneficial effects of estrogen on bone metabolism. Monocytes will be isolated from whole blood and placed in culture. While in culture we will study the cytokines (substance released from inflammatory cells such as monocytes) which modulate bone resorption. These cytokines may be regulated by estrogen and/or Tamoxifen.

他莫昔芬是一种非甾体类抗雌激素药物，用于治疗 乳腺癌 由于其抗雌激素特性，它与雌激素结合 受体，从而阻断雌激素依赖性肿瘤生长。主要是雌激素 骨质疏松症的病因是什么呢？ 在更年期， 雌激素的缺乏会导致骨质流失的增加。 他莫昔芬在a 低雌激素环境，绝经后，似乎有雌激素样 影响并抑制骨吸收。 然而，在体外研究中， 证明他莫昔芬在雌激素的存在下， 雌激素对骨代谢的有益作用。 本研究将 有助于评估雌激素对骨代谢的有益作用。 将从全血中分离单核细胞并置于培养物中。 而 在培养中，我们将研究细胞因子（从细胞中释放的物质）。 炎性细胞如单核细胞），其调节骨吸收。 这些细胞因子可由雌激素和/或他莫昔芬调节。