EFFECT OF TAMOXIFEN ON THE REGULATION OF IL 1 IN MONOCYTE CULTURE

他莫昔芬是一种非类固醇抗雌激素药物，用于治疗 乳腺癌。由于其抗雌激素特性，它与雌激素结合在一起。 受体从而阻断雌激素依赖性肿瘤的生长。雌激素，主要是 缺乏，是导致骨质疏松症的原因之一。在更年期时， 缺乏雌激素会导致骨质流失增加。他莫昔芬 绝经后雌激素水平低下的环境似乎有雌激素样物质。 影响和抑制骨吸收。然而，在体外研究中， 证明他莫昔芬在雌激素存在的情况下实际上抑制了 雌激素对骨代谢的有益作用。这项研究将 有助于评估雌激素对骨代谢的有益作用。 单核细胞将从全血中分离出来，并放置在培养中。而当 在培养中，我们将研究细胞因子(从 炎症细胞，如单核细胞)，调节骨吸收。 这些细胞因子可能受雌激素和/或他莫昔芬的调节。

Tamoxifen, a nonsteroidal antiestrogen drug, is used in the treatment of breast cancer. With its antiestrogen properties, it binds to estrogen receptors thus blocking estrogen dependent tumor growth. Estrogen, mainly the lack of, is instrumental in the cause of osteoporosis. At menopause, the lack of estrogen causes an increase in bone loss. Tamoxifen in a hypoestrogenic environment, post menopause, appears to have estrogen like effects and inhibits bone resorption. In vitro studies, however, demonstrate that Tamoxifen in the presence of estrogen actually inhibits the beneficial effects of estrogen on bone metabolism. This study will help to evaluate the beneficial effects of estrogen on bone metabolism. Monocytes will be isolated from whole blood and placed in culture. While in culture we will study the cytokines (substance released from inflammatory cells such as monocytes) which modulate bone resorption. These cytokines may be regulated by estrogen and/or Tamoxifen.