GOSERELIN ACETATE PLUS IRON VS SHAM PLUS IRON FOR MANAGEMENT OF FIBRO

本研究比较了醋酸戈舍瑞林（zoladex）3个月10.8 mg贮库型加铁剂与假加铁剂用于子宫肌瘤所致缺铁性贫血绝经前女性的术前管理。本研究的主要目的是观察血红蛋白浓度升高的受试者百分比、血液学恢复的受试者百分比以及随机化后血红蛋白的平均升高。 次要目的是比较治疗组间缓解子宫肌瘤相关症状的差异，比较需要输血的受试者数量，比较有资格提供血液用于自体输血的受试者数量，比较肌瘤和总子宫体积的变化，并比较醋酸戈舍瑞林或假手术加铁的安全性和耐受性。

This study is of goserelin acetate (zoladex) 3-month 10.8 mg depot plus iron versus sham plus iron for the preoperative management of premenopausal women with iron deficiency anemia due to uterine fibroids. The primary objectives of this study are to see the percentage of subjects who achieve an increase in hemoglobin concentrations, the percentage of subjects who receive hematologic recovery, and the mean increase in hemoglobin from randomization. The secondary objectives are to compare the differences between treatment groups for the relief of symptoms associated with uterine fibroids, compare the number of subjects requiring blood transfusions, compare the number of subjects who are eligible to provide blood for autologous blood transfusion, compare the changes in fibroid and total uterine volume, and to compare the safety and tolerability of goserelin acetate or sham plus iron.