EFFECT OF TAMOXIFEN ON THE REGULATION OF IL 1 IN MONOCYTE CULTURE

他莫昔芬对单核细胞培养中IL-1的调节作用

• 批准号: 6122120
• 负责人: GLORIA RICHARD-DAVIS
• 金额: $ 2.09万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6122120
• 关键词: bone metabolism; clinical trials; cytokine; estrogens; hormone regulation /control mechanism; human subject; interleukin 1; monocyte; tamoxifen; tissue /cell culture

Tamoxifen, a nonsteroidal antiestrogen drug, is used in the treatment of breast cancer. With its antiestrogen properties, it binds to estrogen receptors thus blocking estrogen dependent tumor growth. Estrogen, mainly the lack of, is instrumental in the cause of osteoporosis. At menopause, the lack of estrogen causes an increase in bone loss. Tamoxifen in a hypoestrogenic environment, post menopause, appears to have estrogen like effects and inhibits bone resorption. In vitro studies, however, demonstrate that Tamoxifen in the presence of estrogen actually inhibits the beneficial effects of estrogen on bone metabolism. This study will help to evaluate the beneficial effects of estrogen on bone metabolism. Monocytes will be isolated from whole blood and placed in culture. While in culture we will study the cytokines (substance released from inflammatory cells such as monocytes) which modulate bone resorption. These cytokines may be regulated by estrogen and/or Tamoxifen.

他莫昔芬是一种非甾体类抗雌激素药物，用于治疗