EFFECT OF MATERNAL CALCIUM SUPPLEMENTATION ON INFANT BONE MINERAL CONTENT

母亲补钙对婴儿骨矿物质含量的影响

• 批准号: 6282879
• 负责人: JORGE A PRADA
• 金额: $ 2.34万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282879
• 关键词: adolescence (12-20); age at pregnancy; bone density; bone development; calcium metabolism; dietary calcium; dietary supplements; human pregnant subject; human subject; infant human (0-1 year); mother /embryo /fetus nutrition; normal ossification; nutrition related tag

Calcium requirements during pregnancy increase significantly to meet the needs of the mother and the developing fetus. This could result in the maternal loss of bone mineral density (up to 3.8% spinal BMD). This loss of BMD may be the combined result of dietary calcium intake falling short of the calcium requirements for pregnancy, and the increased urinary calcium excretion during pregnancy. From our preliminary study of 64 pregnant adolescents, the dietary recall of the previous 24 hours revealed a calculated dietary calcium intake of 978 +/- 532 mg/day, including the 250 mg/day of calcium present in the prenatal supplementation, which is below the RDA for pregnancy. Births from adolescent mothers are known to result in lower birth weight of the individual infants. However, it is not known whether it is associated with altered bone mineral status. The effect of maternal calcium depletion during adolescent pregnancy on the infant BMC has not been studied. The overall aim of this proposal is to determine the effects that the current maternal dietary calcium intake, and calcium supplementation in pregnancy, will have on the infant bone mineral content.

怀孕期间钙的需求量显著增加，以满足 母亲和发育中的胎儿的需要。 这可能导致 母体骨矿物质密度损失（高达3.8%的脊柱BMD）。 这一损失 骨密度的降低可能是膳食钙摄入不足的综合结果 怀孕的钙需求，以及尿钙的增加， 怀孕期间的钙排泄。 根据我们对64个国家的初步研究， 怀孕的青少年，过去24小时的饮食回忆显示， 计算的膳食钙摄入量为978 +/- 532 mg/天，包括 250毫克/天的钙存在于产前补充，这是 低于怀孕的RDA。 据了解，青少年母亲的分娩 导致个别婴儿的出生体重较低。 但据 尚不清楚是否与骨矿物质状态改变有关。 的 青少年妊娠期母亲缺钙对胎儿生长发育的影响 婴儿BMC尚未被研究。 本建议的总体目标是 确定目前母亲膳食钙摄入量的影响， 在孕期补钙，会对婴儿骨骼有影响 矿物质含量