EFFECT OF MATERNAL CALCIUM SUPPLEMENTATION ON INFANT BONE MINERAL CONTENT

母亲补钙对婴儿骨矿物质含量的影响

• 批准号: 6295052
• 负责人: JORGE A PRADA
• 金额: $ 3.1万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6295052
• 关键词: adolescence (12-20); age at pregnancy; bone density; bone development; calcium metabolism; dietary calcium; dietary supplements; human pregnant subject; human subject; infant human (0-1 year); mother /embryo /fetus nutrition; normal ossification; nutrition related tag

Calcium requirements during pregnancy increase significantly to meet the needs of the mother and the developing fetus. This could result in the maternal loss of bone mineral density (up to 3.8% spinal BMD). This loss of BMD may be the combined result of dietary calcium intake falling short of the calcium requirements for pregnancy, and the increased urinary calcium excretion during pregnancy. From our preliminary study of 64 pregnant adolescents, the dietary recall of the previous 24 hours revealed a calculated dietary calcium intake of 978 +/- 532 mg/day, including the 250 mg/day of calcium present in the prenatal supplementation, which is below the RDA for pregnancy. Births from adolescent mothers are known to result in lower birth weight of the individual infants. However, it is not known whether it is associated with altered bone mineral status. The effect of maternal calcium depletion during adolescent pregnancy on the infant BMC has not been studied. The overall aim of this proposal is to determine the effects that the current maternal dietary calcium intake, and calcium supplementation in pregnancy, will have on the infant bone mineral content.

怀孕期间的钙需求量显著增加，以满足母亲和发育中的胎儿的需要。这可能会导致母亲失去骨密度(高达3.8%的脊柱骨密度)。这种骨密度的丧失可能是膳食钙摄入量达不到孕期所需钙，以及孕期尿钙排泄增加的综合结果。从我们对怀孕青少年的初步研究中，对过去24小时的饮食回忆显示，计算出的膳食钙摄入量为978+/-532毫克/天，其中包括产前补充剂中存在的250毫克/天的钙，低于妊娠的RDA。众所周知，青春期母亲的出生会导致单个婴儿出生体重较低。然而，目前还不知道它是否与骨矿物质状态改变有关。青春期妊娠期间母体缺钙对婴儿BMC的影响尚未被研究。这项建议的总体目标是确定当前母亲膳食钙摄入量和孕期补钙对婴儿骨矿含量的影响。