EFFECT OF MATERNAL CALCIUM SUPPLEMENTATION ON INFANT BONE MINERAL CONTENT

怀孕期间钙的需求量显着增加，以满足母亲和发育中的胎儿的需要。 这可能导致母体骨矿物质密度损失（高达3.8%的脊柱BMD）。 这种BMD的损失可能是膳食钙摄入量低于妊娠钙需求量和妊娠期间尿钙排泄增加的综合结果。 从我们对64名怀孕青少年的初步研究中，对过去24小时的饮食回忆显示，计算的膳食钙摄入量为978 +/- 532 mg/天，包括产前补充剂中的250 mg/天钙，这低于怀孕的RDA。 据了解，未成年母亲的分娩会导致婴儿出生体重较低。 然而，尚不清楚它是否与骨矿物质状态改变有关。 尚未研究青春期妊娠期间母体钙缺乏对婴儿BMC的影响。 本建议的总体目标是确定目前母亲膳食钙摄入量和妊娠期钙补充剂对婴儿骨矿物质含量的影响。

Calcium requirements during pregnancy increase significantly to meet the needs of the mother and the developing fetus. This could result in the maternal loss of bone mineral density (up to 3.8% spinal BMD). This loss of BMD may be the combined result of dietary calcium intake falling short of the calcium requirements for pregnancy, and the increased urinary calcium excretion during pregnancy. From our preliminary study of 64 pregnant adolescents, the dietary recall of the previous 24 hours revealed a calculated dietary calcium intake of 978 +/- 532 mg/day, including the 250 mg/day of calcium present in the prenatal supplementation, which is below the RDA for pregnancy. Births from adolescent mothers are known to result in lower birth weight of the individual infants. However, it is not known whether it is associated with altered bone mineral status. The effect of maternal calcium depletion during adolescent pregnancy on the infant BMC has not been studied. The overall aim of this proposal is to determine the effects that the current maternal dietary calcium intake, and calcium supplementation in pregnancy, will have on the infant bone mineral content.