EFFECT OF MATERNAL CALCIUM SUPPLEMENTATION ON INFANT BONE MINERAL CONTENT

母亲补钙对婴儿骨矿物质含量的影响

• 批准号: 6414958
• 负责人: JORGE A PRADA
• 金额: $ 2.85万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6414958
• 关键词: adolescence (12-20); age at pregnancy; bone density; bone development; calcium metabolism; dietary calcium; dietary supplements; human pregnant subject; human subject; infant human (0-1 year); mother /embryo /fetus nutrition; normal ossification; nutrition related tag

Calcium requirements during pregnancy increase significantly to meet the needs of the mother and the developing fetus. This could result in the maternal loss of bone mineral density (up to 3.8% spinal BMD). This loss of BMD may be the combined result of dietary calcium intake falling short of the calcium requirements for pregnancy, and the increased urinary calcium excretion during pregnancy. From our preliminary study of 64 pregnant adolescents, the dietary recall of the previous 24 hours revealed a calculated dietary calcium intake of 978 +/- 532 mg/day, including the 250 mg/day of calcium present in the prenatal supplementation, which is below the RDA for pregnancy. Births from adolescent mothers are known to result in lower birth weight of the individual infants. However, it is not known whether it is associated with altered bone mineral status. The effect of maternal calcium depletion during adolescent pregnancy on the infant BMC has not been studied. The overall aim of this proposal is to determine the effects that the current maternal dietary calcium intake, and calcium supplementation in pregnancy, will have on the infant bone mineral content.

怀孕期间钙的需要量显著增加，以满足母亲和发育中的胎儿的需要。这可能导致产妇骨密度下降（高达3.8%的脊柱骨密度）。这种骨密度的下降可能是饮食钙摄入量低于妊娠期钙需求和妊娠期尿钙排泄增加的综合结果。从我们对64名怀孕少女的初步研究中，对过去24小时的饮食回忆显示，计算出的膳食钙摄入量为978 +/- 532 mg/天，包括产前补充的250 mg/天的钙，低于怀孕的RDA。众所周知，未成年母亲生育的婴儿出生时体重较轻。然而，尚不清楚它是否与骨矿物质状态的改变有关。在青春期怀孕期间，母体钙的缺乏对婴儿BMC的影响还没有研究。这项建议的总体目标是确定当前母亲膳食钙摄入量和怀孕期间钙补充对婴儿骨矿物质含量的影响。