RANDOMIZED CALCIUM TRIAL IN HIGH RISK PREGNANCIES

高风险妊娠的随机钙试验

• 批准号: 6414946
• 负责人: JORGE A PRADA
• 金额: $ 2.85万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6414946
• 关键词: 1,25 dihydroxycholecalciferol; adolescence (12-20); age at pregnancy; age difference; clinical research; diet; dietary calcium; disease /disorder proneness /risk; female; high risk behavior /lifestyle; hormone regulation /control mechanism; human data; mother /embryo /fetus nutrition; nutrient intake activity; nutrition related tag; parathyroid hormones; pregnancy; pregnancy toxemia /hypertension; women's health; young adult human (21-34)

The overall aim of this study is to determine if the calcium intake recommended during pregnancy is sufficient to provide for the high calcium requirements of two groups of high-risk pregnancies, adolescent singleton gestation and adult multiple gestations. The study will determine whether specific abnormalities of calcium and of the calcium regulating hormone, parathyroid hormone (PTH) and 1,25 (OH)2 Vitamin D, the active metabolite of vitamin D (calcitriol), are related to calcium intake in adolescent pregnancies and adult multiple gestation. This study may provide important information that could lead to the understanding of the possible increased calcium needs of these two highly important groups of pregnancies, and provide important information that could lead to the reduction of high blood pressure during pregnancy. This project utilizes the resources of the CRC Core Laboratory only for the above-mentioned determinations. There are no inpatient or outpatient visits.

这项研究的总体目的是确定怀孕期间推荐的钙摄入量是否足以满足两组高危妊娠的高钙需求，即青少年单胎妊娠和成年多胎妊娠。这项研究将确定钙和钙调节激素甲状旁腺激素(PTH)和维生素D(骨化三醇)的活性代谢物1，25(OH)2维生素D的特定异常是否与青少年妊娠和成年多胎妊娠的钙摄入量有关。这项研究可能会提供重要的信息，有助于了解这两个高度重要的妊娠组可能增加的钙需求，并提供可能导致妊娠期高血压降低的重要信息。该项目仅将儿童权利委员会核心实验室的资源用于上述确定。没有住院或门诊就诊。