IDENTIFICATION AND CONTROL OF CANCER RISK

癌症风险的识别和控制

• 批准号: 6173441
• 负责人: ROBERT F HERRICK
• 金额: $ 29.88万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173441
• 关键词: adduct; cancer prevention; cancer risk; carbopolycyclic compound; clinical research; genetic markers; human genetic material tag; human subject; mathematical model; model design /development; neoplasm /cancer; neoplasm /cancer epidemiology; neoplasm /cancer genetics; occupational disease /disorder; occupational hazard

DESCRIPTION: (Adapted from Applicant's Abstract). The major goal of this study is to test the hypothesis that the excess cancer risk among asphalt workers is a result of their occupational exposure, and to assess the role of asphalt exposure as a cancer risk. In addition to investigating the degree to which the observed marker for cancer risk is attributable to occupational asphalt exposure, the relative importance of inhalation and dermal routes of exposure will be assessed to provide the basis for an intervention strategy to reduce that risk. There have been approximately 20 epidemiologic studies done on cancer risk among roofers and highway maintenance workers, and excess risk of cancer for several sites (lung, stomach, non-melanoma skin, and leukemias) have been reported with roofers consistently demonstrating greater risks than highway maintenance workers. Occupational exposure to PAHs has been proposed to explain the excess risk in these two groups, but no detailed exposure assessments have been done to support this association. The plan is to conduct a prospective study, including comprehensive assessment of exposure, to examine the association between exposure to PAH and a biological marker of carcinogen damage in the form of PAH-DNA adducts. The proposed research will: 1) recruit a population of at least 100 workers employed in roofing and highway paving with a range of asphalt exposures; 2) conduct a comprehensive evaluation of their occupational PAH exposure using their work task as the central organizing principle of the exposure assessment; 3) develop a task-based model for estimating the PAH exposures during the one-year prospective study; 4) measure the change in PAH-DNA adduct levels in mononuclear cells of these workers over the working year; 5) evaluate by linear regression the contribution of dermal and respiratory PAH exposure, smoking, diet and other factors to the level of PAH-DNA adducts; 6) develop an intervention strategy to reduce the risk of cancer resulting from occupational PAH exposures, using the information on the relative significance of inhalation and dermal exposure and the task-specific measures of exposure.

描述：（改编自申请人摘要）。 这个项目的主要目标是 这项研究是为了验证沥青中的过度癌症风险的假设， 工人是他们的职业暴露的结果，并评估作用 沥青暴露是一种癌症风险。 除了调查 观察到的癌症风险标志物可归因于 职业沥青暴露，吸入和 将评估皮肤接触途径， 干预策略，以降低风险。 大约有20个 屋顶工人和公路工人患癌症风险的流行病学研究 维修工人，以及几个部位的癌症的过度风险（肺， 胃，非黑色素瘤皮肤，白血病）已报告与屋顶工 比公路养护工人的风险更大。 职业暴露于多环芳烃已被提出来解释过度的风险 在这两组中，但没有进行详细的暴露评估， 支持这个协会。 计划进行一项前瞻性研究，包括全面的 暴露评估，以检查PAH暴露与 和以PAH-DNA加合物形式的致癌物损伤的生物标志物。 拟议的研究将：1）招募至少100名工人 用于屋顶和公路铺设，具有一系列沥青暴露; 2） 使用以下方法对他们的职业PAH暴露进行全面评估 以工作任务为中心， 评估; 3）开发一个基于任务的模型，用于估计PAH暴露 在为期一年的前瞻性研究中; 4）测量PAH-DNA的变化 这些工人在工作年内单核细胞中的加合物水平; 5)通过线性回归评估皮肤和呼吸道的贡献 PAH暴露、吸烟、饮食等因素对PAH-DNA水平的影响 加合物; 6）制定干预战略，以降低癌症风险 职业性多环芳烃暴露所造成的影响， 吸入和皮肤接触的相对重要性， 针对具体任务的暴露措施。

项目成果

Laboratory evaluation of a potential diesel fuel interference in the determination of polycyclic aromatic compounds on dermal samplers.

实验室评估柴油燃料对皮肤采样器测定多环芳香族化合物的潜在干扰。

• DOI: 10.1080/15459620490445444
• 发表时间: 2004
• 期刊: Journal of occupational and environmental hygiene
• 影响因子: 2
• 作者: Weker,RobertA;Herrick,RobertF;Rinehart,RichardD
• 通讯作者: Rinehart,RichardD

Biomarker variance component estimation for exposure surrogate selection and toxicokinetic inference.

用于暴露替代选择和毒代动力学推断的生物标志物方差分量估计。

• DOI: 10.1016/j.toxlet.2010.09.006
• 发表时间: 2010
• 期刊: Toxicology letters
• 影响因子: 3.5
• 作者: Sobus,JonR;Pleil,JoachimD;McClean,MichaelD;Herrick,RobertF;Rappaport,StephenM
• 通讯作者: Rappaport,StephenM