MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION

持续性 HPV 感染的分子流行病学

• 批准号: 6173539
• 负责人: EDUARDO L. FRANCO
• 金额: $ 25.67万
• 依托单位: MCGILL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-11 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173539
• 关键词: Brazil; South American; cancer risk; cervix neoplasms; clinical research; female; genetic polymorphism; genetic strain; histocompatibility typing; human papillomavirus; human subject; longitudinal human study; low socioeconomic status; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplastic process; oncogenic virus; p53 gene /protein; preneoplastic state; serology /serodiagnosis; sex behavior; viral carcinogenesis; virus load; virus related neoplasm /cancer; women's health

DESCRIPTION: This is a competing continuation application for continued study of human papilloma virus (HPV) genital persistent in a large cohort of low income women in Sao Paolo, Brazil, a high risk area for cervical carcinoma. The study focuses on the relationship of oncogenic HPV types on the development of cervical epithelial lesions and carcinoma. Participants undergo a series of questionnaire-based interviews to access sexual behavior and other potentially contributing factors, PAP smears, HPV testing by PCR, HPV serology and cervicography. The objectives are to 1 study incidence and prevalence of persistent cervical HPV in asymptomatic women; 2 verify the hypothesis that persistent HPV increases low and high grade cervical lesions; 3 detect epidemiological determinants of HPV persistence; 4 search for molecular variants associated with cervical lesions; 5 to determine whether HPV viral load is associated with persistence, and low or high grade lesions; and 6 study the role of antibody response to HPV persistence and lesion progression. For the competitive renewal, 2 additional aims are proposed: 7 identity HLA haplotypes associated with HPV persistence and cervical lesions; and 8 test whether p53 polymorphisms confer resistance to HPV persistence and lesion development.

描述：这是一个继续研究的竞争性继续申请 人乳头瘤病毒（HPV）生殖器持久性在一个大的队列低 巴西圣保罗的高收入妇女是宫颈癌的高危地区。的 研究的重点是致癌HPV类型对发展的关系， 宫颈上皮病变和癌。参与者将经历一系列 基于性别的访谈，以了解性行为和其他潜在的 影响因素，PAP涂片，HPV PCR检测，HPV血清学和 宫颈造影其目标是 1 宫颈HPV持续感染发生率和患病率研究 无症状妇女; 2 验证持续性HPV增加低和高的假设 宫颈病变分级; 3 检测HPV持续存在的流行病学决定因素; 4 寻找与宫颈病变相关的分子变异; 5 为了确定HPV病毒载量是否与持久性相关， 以及低或高级别病变;以及 6 研究抗体应答在HPV持续存在和病变中的作用 进展 对于竞争性更新，提出了2个额外目标： 7 与HPV持续感染和宫颈癌相关HLA单倍型 病变;以及 8 测试p53多态性是否赋予对HPV持久性的抗性 和病变发展。