Molecular Epidemiology of Persistent HPV Infection

持续性 HPV 感染的分子流行病学

• 批准号: 6579757
• 负责人: EDUARDO L. FRANCO
• 金额: $ 27万
• 依托单位: MCGILL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-11 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6579757
• 关键词: Brazil; MHC class II antigen; cancer risk; cervix neoplasms; clinical research; female; genetic polymorphism; human papillomavirus; human subject; humoral immunity; insulinlike growth factor; interview; longitudinal human study; neoplasm /cancer epidemiology; neoplastic transformation; p53 gene /protein; pathologic process; serology /serodiagnosis; virus genetics; virus related neoplasm /cancer; women's health

DESCRIPTION (provided by applicant): This competing continuation grant is the second and last request for renewal of CA70269, the original funding for an epidemiologic study of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a low-income female population in Sao Paulo, Brazil. In collaboration with Brazilian colleagues, three of the authors began the study in 1993 in an attempt to understand attributes of the natural history of HPV that could be instrumental in designing strategies for preventing cervical cancer. Considering the public health and economic importance of cervical cancer and the widespread interest in HPV vaccines and in using HPV in cancer screening there is a need for long-ranging multidisciplinary studies of the natural history of HPV. The study accrued 2529 female subjects through March 1997. Subjects have been followed up in scheduled returns every 4 months in the first year, and twice yearly thereafter for a total of 5 years. Participants undergo a questionnaire-based interview have a cervical specimen taken for Pap cytology and HPV testing, and a blood sample drawn for HPV antibody serology. Follow-up will have been completed at the time current funding for the cohort study finishes in August 2002. The study's original objectives (1996-99 funding period) were: (1) to study the prevalence and incidence of persistent HPV infection in asymptomatic women; (2) to verify the hypothesis that persistent HPV infection increases risk of cervical lesions; (3) to search for determinants of persistent cervical HPV infection; (4) to search for molecular variants of HPV that may lead to an increased risk of cervical lesions; (5) to verify the hypothesis that viral burden in the cervix may be correlated with persistent infections and with lesion risk; and (6) to study the antibody response to HPV as a predictor of persistent HPV infection and of lesion risk. In the last successful continuation (1999-02 funding period) these objectives were expanded to include: (7) the search for specific HLA haplotypes associated with HPV persistence and lesion severity, and (8) to test the hypothesis that p53 gene polymorphism may influence resistance against viral persistence and to lesion development. This competing continuation is to conduct in-depth statistical analyses of the database accrued during the study and to add a new objective: (9) to study the role of insulin growth factors in mediating risk of persistent HPV infection and cervical lesions.

描述（由申请人提供）：该竞争性继续资助是CA 70269的第二次也是最后一次续期申请，CA 70269是巴西圣保罗低收入女性人群中人乳头瘤病毒（HPV）感染和宫颈肿瘤自然史流行病学研究的原始资助。在与巴西同事的合作中，三位作者于1993年开始了这项研究，试图了解HPV自然史的属性，这可能有助于设计预防宫颈癌的策略。考虑到宫颈癌的公共卫生和经济重要性以及对HPV疫苗和在癌症筛查中使用HPV的广泛兴趣，需要对HPV的自然史进行长期的多学科研究。 该研究截至1997年3月招募了2529名女性受试者。第一年每4个月对受试者进行一次定期随访，此后每年两次，共随访5年。参与者接受基于宫颈癌的面谈，宫颈标本用于巴氏细胞学和HPV检测，血液样本用于HPV抗体血清学。随访将在2002年8月队列研究的现有资金结束时完成。 研究的最初目标（1996- 1999年资助期）的主要目的是：（1）研究无症状妇女中HPV持续感染的患病率和发生率;（2）验证HPV持续感染增加宫颈病变风险的假设;（3）寻找宫颈HPV持续感染的决定因素;（4）寻找可能导致宫颈病变风险增加的HPV分子变异体;（5）验证宫颈中的病毒负荷可能与持续感染和病变风险相关的假设;（6）研究HPV抗体应答作为HPV持续感染和病变风险的预测因子。在最近一次成功的延续中（1999-02年资助期），这些目标扩展到包括：（7）寻找与HPV持续存在和病变严重程度相关的特定HLA单倍型，（8）检验p53基因多态性可能影响对病毒持续存在和病变发展的抵抗力的假设。这一竞争性延续是为了对研究期间积累的数据库进行深入的统计分析，并增加一个新的目的：（9）研究胰岛素生长因子在介导持续性HPV感染和宫颈病变风险中的作用。

项目成果

Circulating biomarkers of iron storage and clearance of incident human papillomavirus infection.

铁储存和清除人乳头瘤病毒感染事件的循环生物标志物。

• DOI: 10.1158/1055-9965.epi-12-0073
• 发表时间: 2012
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Siegel,ErinM;Patel,Nitin;Lu,Beibei;Lee,Ji-Hyun;Nyitray,AlanG;Huang,Xi;Villa,LuisaL;Franco,EduardoL;Giuliano,AnnaR
• 通讯作者: Giuliano,AnnaR

A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections.

致癌性和非致癌性宫颈人乳头瘤病毒感染危险因素的累积病例对照研究。

• 发表时间: 2000
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
• 作者: Rousseau,MC;Franco,EL;Villa,LL;Sobrinho,JP;Termini,L;Prado,JM;Rohan,TE
• 通讯作者: Rohan,TE

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses.

• DOI: 10.1158/1055-9965.epi-17-0081
• 发表时间: 2017-08
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Sichero L;El-Zein M;Nunes EM;Ferreira S;Franco EL;Villa LL;Ludwig-McGill Cohort Study
• 通讯作者: Ludwig-McGill Cohort Study

Epidemiologic Evaluation of Human Papillomavirus Type Competition and the Potential for Type Replacement Post-Vaccination.

人类乳头瘤病毒类型竞争的流行病学评估和疫苗接种后类型替代的潜力。

• DOI: 10.1371/journal.pone.0166329
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Tota JE;Jiang M;Ramanakumar AV;Walter SD;Kaufman JS;Coutlée F;Richardson H;Burchell AN;Koushik A;Mayrand MH;Villa LL;Franco EL
• 通讯作者: Franco EL

Correlation between cervical HPV DNA detection and HPV16 seroreactivity measured with L1-only and L1+L2 viral capsid antigens.

• DOI: 10.1099/jmm.0.001213
• 发表时间: 2020-06
• 期刊: Journal of medical microbiology
• 影响因子: 3
• 作者: A. Trevisan;J. Candeias;P. Thomann;L. Villa;E. Franco;H. Trottier