HEALTH EFFECTS OF PESTICIDES

工作总结：我正在做两个关于农药的项目。一个是工人健康研究，这是一项关于长期接触农药的农场工人神经功能的研究。在另一项研究中，我正在分析农业健康研究中生活在农场的妇女的生殖健康数据。在工人健康研究中，我牵头分析了暴露评估以及有机磷农药遗传易感性与神经功能之间的关系。利用从颊拭子收集的DNA，我们将分析两个多态性（PON 1和PON 2）之间的关系。这些对氧磷酶多态性被认为在介导心脏病的氧化应激和有机磷农药解毒中发挥作用。对于农业健康研究，我正在分析生活在农场的妇女中农药和其他农场暴露与月经周期异常、胎儿丢失和早产之间关系的数据。我还在努力制定方法，通过收集有关职业农药卫生的信息，改进农药接触的问卷评估。该项目一直受到难以清理数据集的困难的困扰。因为它们是如此之大（超过70，000份）的调查问卷，我们花了过去几年的时间制定数据清理程序，并试图让数据集干净。在接下来的几周内，我们应该有一个干净的数据集，并将能够开始生殖分析。工人健康研究的DNA正在提取过程中，多态性正在分析中。我们应该在接下来的几个月内得到这些数据。- 农药、农民、农场工人、对氧磷酶、环境雌激素、神经系统影响、月经周期、自然流产、早产-人类受试者：仅访谈、实习或调查

Summary of Work: There are two projects I am working on concerning pesticides. One is the Workers Health study, a study of neurologic function among farmworkers chronically exposed to pesticides. In the other I am analyzing data on the reproductive health of women living on farms in the Agricultural health study.For the workers health study, I am taking the lead on analyses on exposure assessment and on the relationship between genetic susceptibility to organophosphate pesticides and neurologic function. Using DNA collected from cheek swabs we will analyze the relationship between two polymorphisms (PON1 and PON2). These paraoxonase polymorphisms are believed to play a role in mediating oxidative stress in heart disease and in detoxifying organophosphate pesticides.For the Agricultural health study, I am analyzing data on the relationship between pesticide and other farm exposures and menstrual cycle abnormalities, fetal loss and preterm births among women living on farms. I am also working on developing methods to improve questionnaire assessment of pesticide exposure by collecting information on occupational pesticide hygiene. This project has been plagued by difficulties with difficulties cleaning the datasets. Because they are so large (over 70,000) questionnaires, we spent the last several years working out data cleaning procedures and trying to get the datasets clean. Within the next few weeks, we should have a clean dataset and will be able to begin the reproductive analyses. The DNA from the workers health study is in the process of being extracted and the polymorphisms are being analyzed. We should have this data in the next few months. - pesticides, farmers, farmworkers, paraoxonase, environmental estrogens, neurologic effects, menstrual cycle, spontaneous abortion, preterm - Human Subjects: Interview, Questionaires, or Surveys Only