TOXICANTS IN HUMAN PLACENTAE AND REPRODUCTIVE OUTCOMES IN UKRAINE

工作总结：目前只有少数关于高环境污染和妊娠的大型研究。我们收集了前苏联共和国乌克兰两个城市地区3 000多名孕妇的数据，据说那里的污染很严重;我们在其中2 200人分娩和住院期间采集了胎盘和母乳。过去两年我们一直在分析这些数据。我们刚刚公布了关于母乳中有机氯和二恶英化合物含量的研究结果。我们还完成了一份关于胎盘中多环芳烃的论文的最后草稿，并已开始研究胎盘中的四种金属。一般来说，尽管有高污染的报告，但该样本中的有毒物质含量较低。一份关于测量前东欧集团污染的困难以及我们如何做到这一点的论文正在计划中。与此同时，我们描述了我们研究的妇女所来自的人口的生殖结果。我们已经完成了一份关于两个城市地区样本中早产率的论文，并将继续研究低出生体重率。我们还将描述乌克兰城市怀孕期间的住院程序，这可以解释人口中的一些显着发现，如胎儿丢失率高，早产率低和出生体重低。- 东欧，东欧集团，生殖，妊娠，污染-人类受试者

Summary of Work: There are only a few large studies of high environmental pollution and pregnancy. We have collected data on over 3,000 pregnant women in two urban areas of Ukraine, a former Soviet republic, where pollution is reputedly high; we took placentas and breast milk from 2,200 of them during delivery and hospitalization. We have been analyzing these data for the last two years. We have just published our findings on the levels of organochlorines and dioxin compounds in human milk. We have also completed the final draft of a paper on polycyclic aromatic hydrocarbons in placenta, and have begun the study of four metals in placenta. In general, the toxicants appear at low levels in this sample in spite of reports of high pollution. A paper on the difficulty of measuring pollution in the former eastern bloc and how we did it is planned. In parallel, we have described the reproductive outcome of the population from which the women we study were drawn. We have finished a paper on the rate of preterm birth in our sample in the two urban areas, and will continue with an examination of the rate of low birth weight. We will also describe hospitalization procedures during pregnancy in urban Ukraine, which may explain some of the notable findings in the population such as the high rate of fetal loss and the low rate of preterm birth and low birth weight. - Eastern Europe, eastern bloc, reproduction, pregnancy, pollution - Human Subjects