PATERNALLY-MEDIATED EFFECTS ON REPRODUCTION

从历史上看，研究遗传和环境因素影响 后代的繁殖和随后的发育 以女性为中心。 在对世界进行了长达一年的评估后， 然而，在文献中，需要对男性介导的 生殖结果是明确的。 因此，我们获得了来自 欧洲妊娠和儿童生存纵向研究 在英格兰的布里斯托进行（"ALSPAC"）。 在ALSPAC研究中， 英格兰埃文郡7,000名分娩妇女的伴侣 1991 - 1992年期间提供了终生职业和有毒接触 历史 这些婴儿和他们的父母将被跟踪七天 年 我们对父母的职业历史进行了编码， 使用英国标准职业代码，并将自我分类， 在工作中和家中接触过 今年有五项研究正在进行或已经完成。本文 报告说父亲的职业与胎儿的生长没有联系， 已提交。 一篇关于同一主题的论文使用了产妇数据， 几乎完成。 父母报告的一致性 第三项研究正在审查他的职业。 一份关于 为医疗目的对性腺进行的放射治疗已经完成;据报道， 胎儿生长的暗示性但不显著的下降。最后 关于流产妇女暴露回忆准确性的论文被接受 女性在流产前报告了更多的暴露 而不是在事件发生后被问到同样的问题。

Historically, research on genetic and environmental factors affecting reproduction and subsequent development of the offspring has been centered on the female. After a year-long assessment of the world literature, however, the need for an epidemiologic study of male-mediated reproductive outcomes was clear. Therefore we have obtained data from the European Longitudinal Study of Pregnancy and Childhood being conducted at Bristol, England ("ALSPAC"). In the ALSPAC study, more than 7,000 partners of women who delivered infants in Avon County, England during 1991-2 provided lifetime occupational and toxic exposure histories. The infants and their parents will be followed for seven years. We have coded occupational histories of both mothers and father, using the British Standard Occupational Codes, and categorized the self- reported exposures on the job and in the home. Five studies are in progress or have been completed this year. The paper reporting no association of paternal occupation with fetal growth has been submitted. A paper on the same subject using maternal data is nearly complete. The concordance between father's and mother's report of his occupation is being examined in the third study. A paper on radiation to the gonads for medical purposes is completed; this reported a suggestive but non-significant decrease in fetal growth. Finally, a paper on accuracy of exposure recall in women who miscarry was accepted for publication; women reported more exposures before they miscarried than when asked the same questions after the event occurred.