PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS

不自主运动的生理分析

基本信息

项目摘要

The goal of this project is to understand the underlying physiological mechanisms of different involuntary movement disorders. We have continued characterization of inhibitory spinal reflex circuits in patients with stiffman (stiffperson) syndrome), with a focus on serial performance of a selected battery of reflex studies at three points in a treatment trial. We continue to study the somatosensory evoked potentials (SEPs) elicited by muscle stretch reflexes in children with type III Gaucher disease (GD3) and healthy age-matched controls. Our results suggest that the SEP in GD3 children are abnormal even when they have no evidence of progressive myoclonus epilepsy, and that the SEP might be a sensitive measure of cortical dysfunction in this disorder. We are doing physiological tremor analysis, including spectral analysis of EMG, accelerometry and EEG-EMG coherence, in persons with the 8-12 Hz component of physiological tremor, essential tremor and parkinsonian tremor. These investigations should help with diagnosis of tremor as well as elucidate the pathophysiology. We are also trying to develop physiological methods for assessment of psychogenic tremor. One test that looks promising is measuring the frequency spectrum of the tremor in one extremity while asking the patient to make movements with specified frequencies with the another extremity. In psychogenic tremor, the tremor may follow the voluntary movement frequency. Flexor reflex studies were done in normal volunteers to compare with patients with Restless legs syndrome (RLS) and Periodic limb movement disorder (PLMD), to test the hypothesis that PLMD of RLS results from enhanced excitability of the spinal cord. Normal subjects showed a dramatic sleep-related inhibition of the flexor reflex response. In contrast, in patients with RLS/PLMD there was significant desinhibition of the flexor reflex response during sleep. Sleep-related inhibition of the monosynaptic H reflex in patients was preserved. The EMG pattern of PLMs closely resembled that of the flexor reflex response. Our study shows abnormal excitability of the spinal cord mechanisms involved in the flexor reflex response in patients with RLS/PLMD and suggests that PLMs in RLS originate in the spinal cord and are facilitated by the loss of supraspinal inhibition. - tremor, myoclonus, chorea, periodic movements in sleep, tic - Human Subjects
这个项目的目标是了解不同非自愿运动障碍的潜在生理机制。我们继续对僵硬人(僵硬人)综合征患者的抑制性脊髓反射回路进行表征,重点是在治疗试验的三个点上选择一组反射研究的系列表现。我们继续研究III型高谢病(GD3)儿童和年龄匹配的健康对照组的肌肉拉伸反射诱发的体感诱发电位(SEPs)。我们的结果表明,GD3儿童的SEP是异常的,即使他们没有证据表明进行性肌阵挛癫痫,SEP可能是这种疾病中皮质功能障碍的敏感指标。我们正在进行生理性震颤分析,包括对生理性震颤、原发性震颤和帕金森氏震颤的8-12赫兹分量的人进行EMG频谱分析、加速度测量和EEG-EMG一致性分析。这些检查有助于震颤的诊断以及阐明震颤的病理生理学。我们还试图开发评估心因性震颤的生理学方法。一种看起来很有希望的测试是测量一端震颤的频谱,同时要求患者用另一端进行指定频率的运动。在心因性震颤中,震颤可能遵循自主运动的频率。对正常志愿者进行屈肌反射研究,并与不宁腿综合征(RLS)和周期性肢体运动障碍(PLMD)患者进行比较,以验证RLS的PLMD是脊髓兴奋性增强所致的假说。正常受试者表现出与睡眠有关的屈肌反射反应的戏剧性抑制。相反,在RLS/PLMD患者中,睡眠中屈肌反射反应明显解除抑制。患者中与睡眠相关的单突触H反射抑制被保留下来。PLM的肌电模式与屈肌反射反应非常相似。我们的研究表明,RLS/PLMD患者屈肌反射反应所涉及的脊髓机制的兴奋性异常,并提示RLS中的PLM起源于脊髓,并通过失去脊髓上的抑制而促进。-震颤、肌阵挛、舞蹈、睡眠中的周期性运动、抽搐-人类受试者

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MARK A HALLETT其他文献

MARK A HALLETT的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MARK A HALLETT', 18)}}的其他基金

PHYSIOLOGICAL ANALYSIS OF VOLUNTARY MOVEMENT
随意运动的生理分析
  • 批准号:
    6290633
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    6842456
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathogenesis And Treatment Of Neurodegenerative Disease
神经退行性疾病的发病机制和治疗
  • 批准号:
    7143815
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Voluntary Movement
随意运动的生理分析
  • 批准号:
    7143847
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS
不自主运动的生理分析
  • 批准号:
    6432895
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    6533319
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    7143846
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathophysiology of Involuntary Movements and Volitional Disorders
不自主运动和意志障碍的病理生理学
  • 批准号:
    7735255
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Voluntary Movement
随意运动的生理分析
  • 批准号:
    6533322
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Involuntary Movement: Physiological Analysis
不自主运动:生理分析
  • 批准号:
    6990024
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

The multifarious studies in the function and the dysfunction of human thalamocortical tract - Neurosurgical treatment in cases with intractable functional diseases of the brain (intractable pain and abnormal involuntary movement)
人类丘脑皮质束功能和功能障碍的多方面研究——脑部顽固性功能性疾病(顽固性疼痛和异常不自主运动)的神经外科治疗
  • 批准号:
    03670671
  • 财政年份:
    1991
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了