Physiological Analysis Of Voluntary Movement

随意运动的生理分析

基本信息

项目摘要

The goal of this project is to learn more about the control of movement in normal humans and in patients with voluntary movement disorders such as Parkinson's disease, cerebellar ataxia, hemiplegia from stroke and dystonia. The tools we use include clinical neurophysiological methods such as electroencephalography, electromyography, and transcranial magnetic stimulation and neuroimaging with positron emission tomography and functional magnetic resonance imaging. Currently active projects in the Section include analysis of the bradykinesia in Parkinson?s disease, studies of recovery from hemiplegia, and the physiology of dystonia. One major scientific target of the Branch is to understand and possibly influence cortical reorganization in patients with congenital or acquired lesions of the central nervous system. A multi-modality approach (neuroimaging with PET and functional MRI, EEG, and transcranial magnetic stimulation) is being used to determine patterns of long-term reorganization of functional brain topography in individual stroke patients. The analysis reveals the best recovery of function comes from reorganization of the damaged hemisphere rather than the contralateral one. In order to explain why people more likely to fall backward than forward, we have been studing subjects perturbed by a translational pushing device. We found that limitations to balance can be predicted by position and velocity of the center of mass of the body. Asymmetry of the tendency to fall is due in part to the asymmetry of the functional foot length. We have done studies of the EEG activity associated with different movements in patients with dystonia. The results indicate that the expected change in movement related potentials with increased complexity does not occur. This may indicate a problem in the process of selection of movements to be made. We are using transcranial magnetic stimulation to investigate the processes of inhibition that occur in muscles that are not selected for particular movements. There appear to be multiple mechanisms. We intend to see if inhibition of any type is defective in patients with dystonia. We are also doing clinical neurophysiological studies of patients with dystonia and their asymptomatic relatives, looking to see if we can find a marker of a genetic propensity to develop dystonia. We have conducted a study to see if training to improve sensory acuity would improve patients with focal limb dystonia. Results do demonstrate improvement in both sensory acuity and motor performance, but the improvement in motor performance is limited in magnitude.
该项目的目标是更多地了解正常人和自主运动障碍患者的运动控制,如帕金森病,小脑共济失调,中风偏瘫和肌张力障碍。我们使用的工具包括临床神经生理学方法,如脑电图,肌电图,经颅磁刺激和神经成像与正电子发射断层扫描和功能磁共振成像。目前活跃的项目在该科包括分析运动迟缓在帕金森?的疾病,从偏瘫恢复的研究,和肌张力障碍的生理学。分支的一个主要科学目标是了解并可能影响先天性或后天性中枢神经系统病变患者的皮质重组。多模态方法(PET和功能性MRI、EEG和经颅磁刺激的神经成像)被用于确定个体卒中患者的功能性脑地形图的长期重组模式。分析表明,功能的最佳恢复来自受损半球的重组,而不是对侧半球。为了解释为什么人们更容易向后摔倒而不是向前摔倒,我们一直在研究受平移推动装置干扰的受试者。我们发现,平衡的局限性可以通过身体质心的位置和速度来预测。跌倒倾向的不对称部分是由于功能性足长的不对称。我们对肌张力障碍患者不同运动时的脑电活动进行了研究。结果表明,运动相关电位的复杂性增加的预期变化并没有发生。这可能表明在选择要进行的动作的过程中存在问题。我们正在使用经颅磁刺激来研究发生在肌肉中的抑制过程,这些肌肉不是为特定的运动而选择的。似乎有多种机制。我们打算看看在肌张力障碍患者中是否有任何类型的抑制是有缺陷的。我们也在对肌张力障碍患者和他们无症状的亲属进行临床神经生理学研究,看看我们是否能找到一个遗传倾向的标记来发展肌张力障碍。我们已经进行了一项研究,看看训练,以提高感觉敏锐度,将改善患者与局灶性肢体肌张力障碍。结果确实证明了感觉敏锐度和运动表现的改善,但运动表现的改善幅度有限。

项目成果

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MARK A HALLETT其他文献

MARK A HALLETT的其他文献

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{{ truncateString('MARK A HALLETT', 18)}}的其他基金

PHYSIOLOGICAL ANALYSIS OF VOLUNTARY MOVEMENT
随意运动的生理分析
  • 批准号:
    6290633
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS
不自主运动的生理分析
  • 批准号:
    6290632
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    6842456
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathogenesis And Treatment Of Neurodegenerative Disease
神经退行性疾病的发病机制和治疗
  • 批准号:
    7143815
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Voluntary Movement
随意运动的生理分析
  • 批准号:
    7143847
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS
不自主运动的生理分析
  • 批准号:
    6432895
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    6533319
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Physiological Analysis Of Involuntary Movements
不随意运动的生理分析
  • 批准号:
    7143846
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Pathophysiology of Involuntary Movements and Volitional Disorders
不自主运动和意志障碍的病理生理学
  • 批准号:
    7735255
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Involuntary Movement: Physiological Analysis
不自主运动:生理分析
  • 批准号:
    6990024
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

The multifarious studies in the function and the dysfunction of human thalamocortical tract - Neurosurgical treatment in cases with intractable functional diseases of the brain (intractable pain and abnormal involuntary movement)
人类丘脑皮质束功能和功能障碍的多方面研究——脑部顽固性功能性疾病(顽固性疼痛和异常不自主运动)的神经外科治疗
  • 批准号:
    03670671
  • 财政年份:
    1991
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
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