Conducting Biomaterials for Nerve Regeneration
Conducting Biomaterials for Nerve Regeneration
批准号:
6338477
负责人:
Silvia D Luebben
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-30 至 2003-03-31
中文摘要
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英文摘要
DESCRIPTION: Clinical studies have shown that electrical stimulation can
accelerate the healing of bone fractures, superficial wounds, and nerve damage.
The development of conducting biomaterials that can be used to deliver electric
stimuli to cultured cells is, therefore, of great interest. Polypyrrole is a an
electronic conducting polymer that has been demonstrated to support growth and
differentiation of neurons in vitro and to favor the in vivo regeneration of
damaged peripheral nerves in rats. Polypyrrole has promising applications in
tissue engineering, but is insoluble and infusible and, therefore, very
difficult to process. This considerably limits its practical applications.
The objective of this project is to develop biocompatible and resorbable
conducting biomaterials based on polypyrrole for tissue engineering
applications that are processable from solution. The new materials will be used
to coat the guidance channels used for repairing peripheral nerve injuries and
will be tested as supports for neuron regeneration in vitro and in vivo. TDA's
material promises to have the same surface and electrical properties of
polypyrrole, yet will be soluble in water or common organic solvents and,
therefore, easily formable into thin films or other complex shapes. TDA's
polymer will be completely biodegradable and have better mechanical properties
than polypyrrole.
PROPOSED COMMERCIAL APPLICATION:
TDA's electrically conducting and resorbable biomaterials will be used as a coating on the
inside surface of nerve guidance channels to stimulate neuron growth and nerve repair.
TDA's biomaterials may find use in other tissue engineering applications including as a
scaffold for epithelial cells and as a bone substitute. TDA's soluble conducting polymer could
also have non-biomedical applications as an antistatic material, for EMI-shielding, in electronic
components and radar-absorbing materials.
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Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
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批准号:8393259
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项目类别:
-
资助金额:$16.2万
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财政年份:2012
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负责人:Silvia D Luebben
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依托单位:
Transcutaneous electrical stimulation of conductive polymers to promote nerve re-
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批准号:7481878
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项目类别:
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资助金额:$23.38万
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财政年份:2008
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负责人:Silvia D Luebben
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依托单位:
Conducting Biomaterials for Nerve Regeneration
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批准号:6952463
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项目类别:
-
资助金额:$37.86万
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财政年份:2001
-
负责人:Silvia D Luebben
-
依托单位:
Conducting Biomaterials for Nerve Regeneration
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批准号:6883550
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项目类别:
-
资助金额:$37.14万
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财政年份:2001
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负责人:Silvia D Luebben
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依托单位:
COMPOSITE MATERIALS FOR HARD TISSUE REPLACEMENT
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批准号:6209587
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项目类别:
-
资助金额:$10.0万
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财政年份:2000
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负责人:Silvia D Luebben
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依托单位: