Magnetic tracking for pharmacodynamic studies

用于药效研究的磁追踪

• 批准号: 6404457
• 负责人: SANKARAN KUMAR
• 金额: $ 9.99万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2002-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6404457
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment safety; biophysics; dipole moment; drug screening /evaluation; gastrointestinal imaging /visualization; magnetic field; magnetic recording system; magnetism; mathematical model; metal complex; microcapsule; model design /development; phantom model; pharmacokinetics; technology /technique development

DESCRIPTION (Provided by Applicant): Quantum Magnetic proposes to develop an instrument, configured as a magnetic gradiometer, that would locate and track a magnetic target in the human digestive tract without the use of radioactive markers. The focus application is to track capsules that are used to study the effects of new medication; however this method may be extended to other applications such as the measurement of gastric motility. Once the target is placed in the capsule, magnetized, and swallowed, its progress will be tracked by the instrument by measuring its magnetic field. When the capsule dissolves, the target will disintegrate, thereby losing its magnetization. The remnants of the magnetic target may then be tracked by measuring their response to an applied magnetic field. The magnetic tracking method will overcome many of the disadvantages of the radioscintigraphic method and make it possible to (a) do measurements in pregnant women and children, (b) avoid patient exposure, however little, to radiation, (c) allow gastroenterologists to use a significantly less expensive instrument, and (d) significantly ease target preparation. In Phase I we will demonstrate the feasibility of the proposed technique and specify the design of a prototype instrument to be built and tested in Phase II. PROPOSED COMMERCIAL APPLICATION: The proposed research will lead to an instrument that will enable gastroenterologists to track objects within the digestive system without using radioactive markers. This instrument will offer significant cost savings and independence to gastroenterologists, and will allow measurements in pregnant women and children to study the effects of new medication. The instrument will be of interest to gastroenterology departments and many pharmaceutical manufacturers worldwide.

描述（由申请人提供）：量子磁性提议开发 仪器配置为磁性梯度计，可以定位和跟踪 不使用放射性的人类消化道中的磁目标 标记。重点应用是跟踪用于研究的胶囊 新药物的影响；但是，此方法可能扩展到其他 诸如胃运动的测量之类的应用。一旦目标是 将其放置在胶囊中，磁化和吞咽，将跟踪其进度 通过仪器测量其磁场。当胶囊溶解时 目标将分解，从而失去其磁化。残余 然后，可以通过测量其对一个的响应来跟踪磁目标 应用的磁场。磁跟踪方法将克服许多 射线激光法的缺点，使（a）做可能 孕妇和儿童的测量，（b）避免患者暴露， 多么少，辐射，（c）允许胃肠病学家使用 明显价格较低的乐器，（d）明显简化目标 准备。在第一阶段，我们将证明提议的可行性 技术并指定要构建的原型仪器的设计和 在第二阶段测试。 拟议的商业应用： 拟议的研究将导致一种工具，该工具将使胃肠病学家能够 在不使用放射性标记的情况下跟踪消化系统中的对象。 该工具将提供大量的成本节省和独立性 胃肠病学家，并将允许孕妇和儿童进行测量 研究新药物的影响。该工具将很感兴趣 全球胃肠病学部门和许多制药制造商。