Improved Susceptometry to Measure Body Iron Stores

改进的电感受计测量体内铁储备

• 批准号: 6913994
• 负责人: SANKARAN KUMAR
• 金额: $ 26.14万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6913994
• 关键词: bioengineering /biomedical engineering; biomagnetism measurement; biomedical equipment development; clinical research; cost effectiveness; diagnosis design /evaluation; diagnosis quality /standard; ferritin; hereditary hemochromatosis; human subject; iron; iron metabolism; iron poisoning; liver; molecular /cellular imaging; noninvasive diagnosis; obesity; thalassemia

DESCRIPTION (provided by applicant): This R21 program will fundamentally improve the precision and reduce the cost of magnetic susceptometry for noninvasive measurements of body iron stores. Where existing susceptometers use expensive SQUID sensors that require liquid helium, the new susceptometer will use inexpensive magnetic sensors working at room temperature. In preliminary studies, a first-generation susceptometer with room-temperature sensors showed a good correlation (r=0.98) with an existing SQUID system. The next-generation susceptometer will resolve lower iron levels, in fatter patients, than any existing susceptometer. As a model system, this program focuses on liver iron measurements, which are the best indicator of total body iron. Innovative susceptometer coil geometry will minimize errors due to the susceptibility responses of the lung and abdominal wall. Additional errors in current measurement systems will be further reduced, after correcting for lung and abdominal-wall susceptibilities, as well as by improving the water bag that compensates for the diamagnetic background response of the body. These improved susceptometry techniques may ultimately be used to measure iron in the brain, heart and other organs, and to detect tissue-specific magnetic tracers that highlight certain molecules and cell types, signal the presence of cancers, or indicate the function of the lymph nodes, liver and spleen.

描述（由申请人提供）： 该R21计划将从根本上提高精度，并降低成本的磁电阻测量的非侵入性测量身体铁存储。现有的超导磁电阻计使用昂贵的SQUID传感器，需要液氦，而新的超导磁电阻计将使用在室温下工作的廉价磁传感器。在初步研究中，第一代室温传感器温度计显示出良好的相关性（r=0.98）与现有的SQUID系统。下一代的铁含量计将解决较低的铁水平，在肥胖患者，比任何现有的铁含量计。作为一个模型系统，该计划侧重于肝脏铁测量，这是全身铁的最佳指标。创新的磁感应强度计线圈几何形状将最大限度地减少由于肺和腹壁的敏感性响应而引起的误差。在校正肺和腹壁的磁化率之后，以及通过改进补偿身体的抗磁背景响应的水袋，将进一步减少当前测量系统中的额外误差。 这些改进的磁共振技术最终可能用于测量大脑、心脏和其他器官中的铁，并检测组织特异性磁示踪剂，这些示踪剂突出显示某些分子和细胞类型，发出癌症存在的信号，或指示淋巴结、肝脏和脾脏的功能。