Magnetic Tracking for Drug Delivery and Motility Studies

用于药物输送和运动研究的磁跟踪

• 批准号: 6801010
• 负责人: SANKARAN KUMAR
• 金额: $ 16.75万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-16 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801010
• 关键词: X ray; autoradiography; bioengineering /biomedical engineering; biosensor device; clinical research; dosage forms; drug delivery systems; gastrointestinal function; gastrointestinal motility /pressure; human subject; magnetic field; magnetism; oral administration; technology /technique development

DESCRIPTION (provided by applicant): The applicants propose a non-radioactive magnetic tracer system to track an oral drug formulation through the digestive tract, and determine the site at which it dissolves. The dosage form is labeled with an inert magnetic material. An array of magnetic sensors measures its magnetic field, and determines its location as a function of time. The dosage form's disintegration is marked by decrease in its magnetic moment. The proposed system, using inexpensive sensor technology, will achieve tracking errors of several mm, with a small amount of magnetic taggant that does not perturb the behavior of the dosage form. The R21 program will (1) test how much taggant can be used without perturbing the dosage form, (2) verify that the sensor system can track that much taggant with adequate accuracy, (3) observe the dissolution of dosage forms in vitro and (4) validate the magnetic tracking in vivo, using x-rays and scintigraphy. This system will be cheaper and more widely available than existing radioscintigraphy methods, and will be applicable to children, pregnant women and elderly subjects. These capabilities will have wide applications in the validation of colonic and enteric drug delivery systems, as well as the diagnosis of gastrointestinal motility disorders.

描述（由申请人提供）： 申请人提出了一种非放射性磁性示踪剂系统，以通过消化道跟踪口服药物制剂，并确定其溶解的部位。 该剂型用惰性磁性材料标记。 磁传感器阵列测量其磁场，并确定其位置作为时间的函数。 剂型的崩解以其磁矩的降低为标志。 所提出的系统，使用廉价的传感器技术，将实现几毫米的跟踪误差，与少量的磁性标签剂，不扰乱剂型的行为。 R21程序将（1）测试在不干扰剂型的情况下可以使用多少标记物，（2）验证传感器系统可以以足够的准确度跟踪那么多标记物，（3）观察体外剂型的溶出度，以及（4）使用X射线和磁共振成像验证体内磁跟踪。 该系统将比现有的放射闪烁照相方法更便宜，更广泛地使用，并将适用于儿童、孕妇和老年受试者。 这些能力将在结肠和肠道给药系统的验证以及胃肠动力障碍的诊断中具有广泛的应用。