Magnetic Tracking for Drug Delivery and Motility Studies

用于药物输送和运动研究的磁跟踪

• 批准号: 6801010
• 负责人: SANKARAN KUMAR
• 金额: $ 16.75万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-16 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801010
• 关键词: X ray; autoradiography; bioengineering /biomedical engineering; biosensor device; clinical research; dosage forms; drug delivery systems; gastrointestinal function; gastrointestinal motility /pressure; human subject; magnetic field; magnetism; oral administration; technology /technique development

DESCRIPTION (provided by applicant): The applicants propose a non-radioactive magnetic tracer system to track an oral drug formulation through the digestive tract, and determine the site at which it dissolves. The dosage form is labeled with an inert magnetic material. An array of magnetic sensors measures its magnetic field, and determines its location as a function of time. The dosage form's disintegration is marked by decrease in its magnetic moment. The proposed system, using inexpensive sensor technology, will achieve tracking errors of several mm, with a small amount of magnetic taggant that does not perturb the behavior of the dosage form. The R21 program will (1) test how much taggant can be used without perturbing the dosage form, (2) verify that the sensor system can track that much taggant with adequate accuracy, (3) observe the dissolution of dosage forms in vitro and (4) validate the magnetic tracking in vivo, using x-rays and scintigraphy. This system will be cheaper and more widely available than existing radioscintigraphy methods, and will be applicable to children, pregnant women and elderly subjects. These capabilities will have wide applications in the validation of colonic and enteric drug delivery systems, as well as the diagnosis of gastrointestinal motility disorders.

描述（由申请人提供）： 申请人提出了一个非放射性磁示踪剂系统，以通过消化道跟踪口服药物制剂，并确定其溶解的位置。 剂型用惰性磁料标记。 一系列磁传感器测量其磁场，并确定其位置是时间的函数。 剂型的分解是其磁矩减少的标志。 提出的使用廉价传感器技术的系统将实现几毫米的跟踪误差，并没有少量的磁性标记，而不会扰动剂型的行为。 R21程序将（1）测试可以在不扰动剂型的情况下使用多少taggant，（2）验证传感器系统可以以足够的精度跟踪这么多标记，（（3）使用X-Rays和Scintigraphy在体外观察体外的剂量和（4）验证磁性跟踪。 该系统将比现有的射线激光方法更便宜，更广泛，并且适用于儿童，孕妇和老年人。 这些功能将在验证结肠和肠药递送系统以及胃肠道运动障碍的诊断中具有广泛的应用。