Hematopoietic Support by Adipose-Derived Stromal Cells
Hematopoietic Support by Adipose-Derived Stromal Cells
批准号:
6435095
负责人:
Jeffrey Martin Gimble
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-06-18 至 2001-12-17
中文摘要
骨髓移植需要大量的多能造血
英文摘要
Bone marrow transplantation requires large numbers of pluripotent hematopoietic
stem cells to achieve a successful clinical outcome. Therefore, there is a pressing
medical need for methods to expand stem cells ex vivo and accelerate their
engraftment in vivo. These steps may be supported by cytokine-producing stromal
cells. The scientists at Artecel Sciences have developed proprietary techniques to
isolate and culture human stromal cells from adipose tissue that can be used for
autologous and allogeneic transplantation. This SBIR investigates the hypotheses
that adipose derived stromal cells will (1) support hematopoietic progenitor cell
proliferation and differentiation in vitro and (2) accelerate their engraftment in vivo.
Aim 1 (Phase I) will demonstrate that human adipose derived stromal cells will
support proliferation of multipotent and pluripotent hematopoietic progenitors in
short and long term cultures using flow cytometric and methylcellulose assays. This
work provides a foundation for Phase H studies to determine: (Aim 3) The ability of
ex vivo expanded hematopoietic progenitors to repopulate sublethally irradiated
NOD/SCID mice; (Aim 4) The ability of adipose derived stromal cells to accelerate
hematopoietic stem cell engraftment in sublethally irradiated NOD/SCID mice.
PROPOSED COMMERCIAL APPLICATION:
This SBIR will develop technology with application to all patients receiving bone
marrow transplantation. Each year, 20,000+ patients under this therapy at an
individual cost of $100,000. Artecel Sciences technology has the potential to
significantly reduce the clinical and financial burden of these procedures.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
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批准号:9336501
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资助金额:$40.4万
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财政年份:2016
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负责人:Jeffrey Martin Gimble
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依托单位:
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批准号:8536479
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资助金额:$2.94万
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财政年份:2012
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依托单位:
Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
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批准号:9339502
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项目类别:
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资助金额:$60.99万
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财政年份:2012
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依托单位:
Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
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批准号:8368987
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项目类别:
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资助金额:$18.6万
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财政年份:2012
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依托单位:
Distinguishing adipose stromal vs. stem cells by serial transplantation
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批准号:8366995
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项目类别:
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资助金额:$23.44万
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财政年份:2012
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负责人:Jeffrey Martin Gimble
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依托单位:
Botannical Extract Library Screeninig with Human ADAS Cells
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批准号:7478265
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项目类别:
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资助金额:$22.9万
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财政年份:2008
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负责人:Jeffrey Martin Gimble
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依托单位:
LOUISIANA COBRE: OBESITY & DIABETES RES: CELL BIOLOGY CORE
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批准号:7382258
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项目类别:
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资助金额:$19.41万
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财政年份:2006
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负责人:Jeffrey Martin Gimble
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依托单位:
Spinal Fusion Using Adipose Derived Adult Stem Cells
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批准号:6928684
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项目类别:
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资助金额:$10.0万
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财政年份:2005
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负责人:Jeffrey Martin Gimble
-
依托单位:
CIRCADIAN MECHANISMS REGULATING OSTEOGENESIS
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批准号:6857660
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项目类别:
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资助金额:$18.03万
-
财政年份:2004
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负责人:Jeffrey Martin Gimble
-
依托单位:
CIRCADIAN MECHANISMS REGULATING OSTEOGENESIS
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批准号:6954223
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项目类别:
-
资助金额:$18.93万
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财政年份:2004
-
负责人:Jeffrey Martin Gimble
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依托单位:
Adipose Stromal Cells for Soft Tissue Bioengineering
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批准号:6457542
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项目类别:
-
资助金额:$10.11万
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财政年份:2001
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负责人:Jeffrey Martin Gimble
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依托单位:
USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERS
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批准号:6294179
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项目类别:
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资助金额:$16.0万
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财政年份:1999
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负责人:Jeffrey Martin Gimble
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依托单位:
USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERS
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批准号:6532983
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项目类别:
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资助金额:$7.85万
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财政年份:1999
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负责人:Jeffrey Martin Gimble
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依托单位:
GENE REGULATION IN LYMPHOHEMATOPOIETIC STROMAL CELLS
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批准号:2094021
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项目类别:
-
资助金额:$10.08万
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财政年份:1989
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负责人:Jeffrey Martin Gimble
-
依托单位:
GENE REGULATION IN LYMPHOHEMOPOIETIC STROMAL CELLS
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批准号:3459669
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项目类别:
-
资助金额:$8.57万
-
财政年份:1989
-
负责人:Jeffrey Martin Gimble
-
依托单位:
GENE REGULATION IN LYMPHOHEMATOPOIETIC STROMAL CELLS
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批准号:2376845
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项目类别:
-
资助金额:$2.15万
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财政年份:1989
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负责人:Jeffrey Martin Gimble
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依托单位:
GENE REGULATION IN LYMPHOHEMATOPOIETIC STROMAL CELLS
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批准号:2686106
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项目类别:
-
资助金额:$8.24万
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财政年份:1989
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负责人:Jeffrey Martin Gimble
-
依托单位:
GENE REGULATION IN LYMPHOHEMOPOIETIC STROMAL CELLS
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批准号:2094017
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项目类别:
-
资助金额:$7.6万
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财政年份:1989
-
负责人:Jeffrey Martin Gimble
-
依托单位:
GENE REGULATION IN LYMPHOHEMATOPOIETIC STROMAL CELLS
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批准号:2094020
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项目类别:
-
资助金额:$9.6万
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财政年份:1989
-
负责人:Jeffrey Martin Gimble
-
依托单位:
GENE REGULATION IN LYMPHOHEMOPOIETIC STROMAL CELLS
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批准号:3459671
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项目类别:
-
资助金额:$9.07万
-
财政年份:1989
-
负责人:Jeffrey Martin Gimble
-
依托单位:
海外基金