Optical Sensor for LDL and HDL Cholesterol Determination

描述：(申请人摘要)水平升高之间的联系 低密度脂蛋白胆固醇(LDL-C)与早产风险增加 冠心病是公认的疾病。此外，水平的提高 胆固醇水平正常的低密度脂蛋白胆固醇水平会增加患心脏病的风险 冠心病。另一方面，高密度脂蛋白胆固醇 (高密度脂蛋白-C)通常被观察到具有保护作用。速溶胆固醇 目前市场上的测量试剂盒只能测量总胆固醇 内容。他们无法量化低密度脂蛋白胆固醇(LDL-C) 和高密度脂蛋白胆固醇(HDLc)。智能光纤 内部监督系统(IOS)，与联合国儿童基金会联合主任卡罗尔·沃森博士合作 加州大学洛杉矶分校胆固醇和血脂管理中心 安吉。力求设计和建造一种低成本、一步到位的。自校准 同时定量测定低密度脂蛋白胆固醇的胆固醇传感器 和新鲜人体血清中的高密度脂蛋白胆固醇。建议的传感器经过内部校准。 以说明测量中的任何误差。创新的光学设计和 化验格式确保光学阅读器的成本将约为100美元， 每次测试的费用约为2美元。这项检测中使用的校准程序 会使这种传感器不受基质影响，而且血清样本可以 直接测试。 建议的商业应用： IOS的胆固醇传感器有望准确、即时地报告高密度脂蛋白和 低密度脂蛋白含量。预计医务室和个人将很快接受这一点 实验室检测的低成本替代方案。此外，预计这一进程的发展 技术将导致一系列积极主动的家庭健康系统和系统 与患者的医疗提供者互动。

DESCRIPTION: (Applicant's abstract) The association between elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature coronary heart disease is well established. Further, an increase in the level of LDL-C with normal levels of cholesterol can result in an increased risk for coronary heart disease. On the other hand, high-density lipoprotein cholesterol (HDL-C) is often observed to have a protective effect. The instant cholesterol measurement kits currently on the market can only measure the total cholesterol content. They cannot quantify the low-density lipoprotein cholesterol (LDL-C) and high-density liprotein cholesterol (HDL-C) separately. Intelligent Optical Systems (IOS), in collaboration with Dr. Karol E. Watson, Co-Director of the Cholesterol and Lipid Management Center at the Unversity of California, Los Angeles. seeks to design and construct a low-cost, single-step. self-calibrated cholesterol sensor for the simultaneous, quantitative determination of LDL-C and HDL-C from fresh human serum. The proposed sensor is internally calibrated to account for any errors in the measurement. The innovative optical design and assay format ensures that the cost of the optical reader will be about $100 and each test will cost about $2.00. The calibration procedures used in this assay will make this sensor immune to matrix effects, and serum samples can be directly tested. PROPOSED COMMERCIAL APPLICATION: IOS's cholesterol sensor is expected to accurately, and instantly, report the HDL-C and LDL-C content. Medical offices and individuals are expected to quickly embrace this low-cost alternative to lab testing. In addition, it is expected that the development of this technology will lead to a family of proactive home-health systems and systems that interact with the patient's medical provider.