MICROWAVE RADIOMETERS FOR HYPERTHERMIA ANTENNA ARRAYS

描述(改编自申请者摘要)：长期目标 本节目旨在提高热疗患者的疗效。 覆盖在等高线上的大面积的浅表皮肤病 解剖，如乳腺癌或斑块的胸壁复发 牛皮癣，为了达到这一目标，我们建议结合微波 非侵入性测量人体表面下组织温度的辐射计 经确认的低温阵列应用系统已在临床上使用 加州大学旧金山分校(UCSF)治疗胸壁复发 乳腺癌。在UCSF系统中加入温度传感器 可以更安全地均匀加热病变组织，并 比现在更高的治疗温度。这将显著地 提高治疗效果，扩大患者数量 可以通过热疗有效治疗的浅表性疾病。这个 第一阶段计划的具体目标是开发一种快速读取两个频率 微波辐射计，并将其集成到多个元素中 共形阵列。随后第二阶段和第三阶段工作的目标将是 建立生产低成本定制形状(患者和 现场特定)辐射控制的共形阵列用于加热大型 地表性疾病。 建议的商业应用： 拟议的集成非侵入性温度传感，使用微波辐射计， 热疗天线阵列在临床治疗浅表疾病中的广泛应用 乳腺癌和轻中度乳腺癌的胸壁复发等组织疾病 斑块型牛皮癣。赛尔逊公司，马里兰州银泉热疗制造商 已获得多项MMTP专利许可的设备公司已表示有兴趣 辐射控制共形阵列施加器和多通道的商业化 915 MHz电源设备。

DESCRIPTION (Adapted from Applicant's Abstract): The long-term objective of this program is to improve the efficacy of hyperthermia treatments for patients with superficial skin diseases that cover large areas overlying contoured anatomies, such as chestwall recurrence of breast carcinoma or plaque psoriasis, To accomplish this objective, we propose to incorporate microwave radiometers that non-invasively measure subsurface tissue temperature into the Conformed Hypethermia Array Applicator System already in clinical use at the University of California, San Francisco (UCSF) to treat chestwall recurrence of breast carcinoma. The incorporation of temperature sensors into the UCSF system would make it possible to safely heat diseased tissues more uniformly and to higher therapeutic temperatures than is possible now. This would significantly increase the efficacy of the treatments and expand the number of patients with superficial disease that can be treated effectively with hyperthermia. The specific aim of the Phase I program is to develop a fast reading two frequency microwave radiometer and integrate it into the multiple elements of the Conformal Arrays. The goal of subsequent Phase II and III efforts will be to set up the capability for production of low cost custom shaped (patient and site specific) radiometrically controlled Conformal Arrays for heating large area surface disease. PROPOSED COMMERCIAL APPLICATION: The proposed integration of non-invasive temperature sensing, using microwave radiometers, with the hyperthermia antenna array should find wide use in clinics for treating superficial tissue diseases such as chestwall recurrence of breast carcinoma and mild to moderate plaque psoriasis. Celsion Corporation, a Silver Spring, MD manufacturer of hyperthermia equipment which has licensed several MMTP patents, has expressed interest in commercializing the radiometrically controlled Conformal Array applicator and multi-channel 915 MHz power equipment.