MICROWAVE RADIOMETERS FOR HYPERTHERMIA ANTENNA ARRAYS

描述（改编自申请人的摘要）： 该项目旨在提高患者热疗的疗效， 具有覆盖大面积覆盖轮廓的浅表皮肤病 解剖结构，如乳腺癌或斑块的胸壁复发 牛皮癣，为了实现这一目标，我们建议将微波 非侵入性测量皮下组织温度的辐射计 已在临床使用的合格低温阵列施加器系统 加州大学旧金山分校弗朗西斯科（UCSF）治疗胸壁复发的 乳腺癌将温度传感器纳入UCSF系统 可以安全地更均匀地加热患病组织， 更高的治疗温度。这将大大 提高治疗效果，扩大患者数量， 可以通过热疗有效治疗的浅表疾病。的 第一阶段计划的具体目标是开发一种快速阅读两个频率 微波辐射计，并将其集成到多个元素的 共形阵列。随后第二和第三阶段工作的目标是 建立生产低成本定制形状（患者和 特定地点）辐射控制的保形阵列，用于加热大型 表面疾病。 拟定商业应用： 所提出的使用微波辐射计的非侵入式温度传感的集成， 与热疗天线阵列应该找到广泛的使用在临床治疗浅表 组织疾病，如乳腺癌胸壁复发和轻至中度 斑块型银屑病 Celsion Corporation，一家位于马里兰州银泉的热疗制造商 已获得多项MMTP专利授权的设备，已表示有兴趣 将辐射控制的共形阵列施用器和多通道 915 MHz电源设备。

DESCRIPTION (Adapted from Applicant's Abstract): The long-term objective of this program is to improve the efficacy of hyperthermia treatments for patients with superficial skin diseases that cover large areas overlying contoured anatomies, such as chestwall recurrence of breast carcinoma or plaque psoriasis, To accomplish this objective, we propose to incorporate microwave radiometers that non-invasively measure subsurface tissue temperature into the Conformed Hypethermia Array Applicator System already in clinical use at the University of California, San Francisco (UCSF) to treat chestwall recurrence of breast carcinoma. The incorporation of temperature sensors into the UCSF system would make it possible to safely heat diseased tissues more uniformly and to higher therapeutic temperatures than is possible now. This would significantly increase the efficacy of the treatments and expand the number of patients with superficial disease that can be treated effectively with hyperthermia. The specific aim of the Phase I program is to develop a fast reading two frequency microwave radiometer and integrate it into the multiple elements of the Conformal Arrays. The goal of subsequent Phase II and III efforts will be to set up the capability for production of low cost custom shaped (patient and site specific) radiometrically controlled Conformal Arrays for heating large area surface disease. PROPOSED COMMERCIAL APPLICATION: The proposed integration of non-invasive temperature sensing, using microwave radiometers, with the hyperthermia antenna array should find wide use in clinics for treating superficial tissue diseases such as chestwall recurrence of breast carcinoma and mild to moderate plaque psoriasis. Celsion Corporation, a Silver Spring, MD manufacturer of hyperthermia equipment which has licensed several MMTP patents, has expressed interest in commercializing the radiometrically controlled Conformal Array applicator and multi-channel 915 MHz power equipment.