Microwave Treatment of Localized Prostate Cancer

描述（由申请人提供）：所提出的具体目标 第二阶段的计划是设计，制造，并在狗的前列腺测试， 用于局部前列腺癌的高温治疗的改进的仪器。 该仪器将使用两个配合经直肠和经尿道微波 球囊导管安全均匀地将患病前列腺加热到最佳温度 治疗温度将通过以下方式监测治疗温度： 热电偶和数字微波辐射计。建议的热疗 仪器将符合所有适用的临床安全标准， 准备在后续项目中进行临床试验。仪器将 自给自足前列腺温度将由微处理器优化 自动确定微波功率的适当数量 通过每个微波气球导管进行广播。 增加微波球囊导管产生的高温， 放射治疗[外照射或植入治疗]可预期产生 在改善局部控制和患者的总体生存率， 前列腺癌双微波球囊热疗可提高质量 这些病人由于产生了 生物支架在他们的尿道，也应该证明是有用的， 局部复发患者姑息性治疗独立疗法 放射治疗后。 拟定商业应用： 前列腺癌影响许多男性，总体治疗费用极高。 所提出的方法具有提供辅助治疗的潜力， 在“门诊”的基础上进行，以提高患者的生存率， 用外部束或植入治疗放射治疗。 新型导尿管 在拟议的计划和相关的热疗设备期间开发， 成为重要的商业产品。

DESCRIPTION (Provided by the Applicant): The specific aims of the proposed Phase II program are to design, fabricate, and test in the prostates of dogs an improved instrument for hyperthermia treatments of localized prostate cancer. The instrument will use two cooperating transrectal and transurethral microwave balloon catheters to safely and uniformly heat diseased prostates to optimum therapeutic temperatures. Treatment temperatures will be monitored by means of therrnocouples and a digital microwave radiometer. The proposed hyperthermia instrument will conform to all applicable clinical safety standards and will be ready for clinical trials in a follow-on program. The instrument will be self-contained. Prostate temperatures will be optimized by a microprocessor that automatically determines the appropriate amount of microwave power to be broadcast by each microwave balloon catheter. The addition of hyperthermia produced by microwave balloon catheters to radiation therapy [external beam or implant therapy1 can be expected to result in improved local control and overall survival rates in patients with localized prostate cancer. Dual microwave balloon hyperthermia would improve the quality of life of those patients that have constricted urethras by producing biological stents in their urethras, and should also prove useful as a stand-alone therapy for palliative treatments of patient with local recurrences after radiation therapy. PROPOSED COMMERCIAL APPLICATION: Prostatic cancer affects many men and the overall treatment costs are extremely high. The proposed approach has the potential for providing and adjuvant treatment that may be performed on an "out-patient" basis to improve the survival rates in patients being treated with external beam or implant therapy radiation. The new type of catheters developed during the proposed program and the associated hyperthermia equipment will be important commercial products.