Wearable Monitor for Recording the Activity of Brown Adipose Tissue

用于记录棕色脂肪组织活动的可穿戴监视器

• 批准号: 8779862
• 负责人: FRED STERZER
• 金额: $ 14.99万
• 依托单位: MMTC, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779862
• 关键词: Adrenergic beta-Antagonists; Adult; Adverse effects; Affect; Alcohol consumption; Authorization documentation; Brown Fat; Burn injury; Caffeine; Calories; Cause of Death; Child; Clothing; Data Storage and Retrieval; Desire for food; Development; Devices; Diabetes Mellitus; Digestive System Disorders; Drug usage; Elements; Energy Metabolism; Equipment; Exploratory/Developmental Grant; Exposure to; Fatty acid glycerol esters; Funding; Goals; Hour; Human Volunteers; Individual; Institutes; Institutional Review Boards; Joints; Kidney Diseases; Measurement; Measures; Medical; Memory; Metabolic; Methods; Modeling; Monitor; Noise; Obesity; Pharmaceutical Preparations; Phase; Positron-Emission Tomography; Prevalence; Procedures; Process; Protocols documentation; Public Health; Relative (related person); Reporting; Scanning; Simulate; Site; Skin; Small Business Innovation Research Grant; Smoking; Temperature; Testing; Time; Tissues; Universities; Variant; Vertebral column; Weather; combat; design; diet and exercise; digital; dosage; drug development; fighting; improved; instrument; instrumentation; microwave electromagnetic radiation; miniaturize; operation; programs; prototype; public health relevance

DESCRIPTION (provided by applicant): Brown Adipose Tissues (BAT) are tissues that when activated become metabolically active and take calories from normal white fat and burn them. Safe methods for creating and activating (BAT) would therefore be of great value in fighting obesity, a leading preventable cause of death with increasing prevalence in adults and children and one of the most serious public health problems of the 21st century. Current efforts to develop BAT stimulation paradigms are hindered by the inability to continuously monitor the activity of BAT with available medical scans. Positron Emission Tomography (PET) scans and other similar types of scanners that can detect activated BAT use large, expensive equipment and are only useful for providing single snapshots in time of the existence of activated BAT. The proposed Phase I SBIR program is for the development of monitors that can safely, noninvasively, and continuously record the activity of BAT of an individual over a period of at least 24 hours and that can be worn by the individuals while carrying out their normal activities. The wearable BAT monitors will be miniaturized and improved versions of the large instruments that were successfully used (P<0.01) to detect activated BAT by measuring the microwave thermal noise emitted by activated BAT in a recently completed joint Johns Hopkins University/MMTC R21 program funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) entitled "Non-Invasive Measurements of Brown Adipose Tissues", and will include miniaturized devices for storing the measured activity of BAT for periods of at least 24 hours. The availability of wearable continuous BAT activation monitors would be of great value not only in the development of drugs that can activate BAT without causing unacceptable side effects, the first obesity drugs that would affect energy expenditure rather than appetite, but also in answering the following types of important questions: How long do activations and degree of activations of BAT due to exposure to cold last as functions of durations of exposures and temperatures? How long and how deep do deactivations of BAT due to adrenergic beta-blockers last as functions of dosages and are there other widely used drugs that deactivate BAT? To what extend do exercise, diet, smoking, consumption of alcohol, caffeine, type of clothing in cold weather, etc., affect the activity of BAT? For any safe drugs tht can enhance the metabolic activity of BAT, how long does this activation last, how much of such drugs does a particular individual have to take to get a significant increase in the metabolic activity of BAT?

描述(申请人提供)：棕色脂肪组织(BAT)是一种组织，当被激活时会变得代谢活跃，并从正常的白色脂肪中获取卡路里并燃烧它们。因此，创造和激活(BAT)的安全方法在抗击肥胖方面将具有重要价值。肥胖是一种主要的可预防的死亡原因，成人和儿童的发病率不断上升，也是21世纪最严重的公共卫生问题之一。目前开发BAT刺激范例的努力由于无法利用可用的医学扫描连续监测BAT的活动而受到阻碍。正电子发射断层扫描(PET)和其他可以检测激活的BAT的类似类型的扫描仪使用大型、昂贵的设备，并且仅用于在存在激活的BAT时提供单次快照。拟议的第一阶段SBIR计划是为了开发能够安全、非侵入性地连续记录个人在至少24小时内的BAT活动的监视器，并且可以在个人进行正常活动时佩戴。可穿戴BAT监测器将是成功使用(P&lt；0.01)的大型仪器的小型化和改进版本，通过测量激活的BAT发出的微波热噪声来检测激活的BAT，该计划最近由约翰·霍普金斯大学/MMTC R21联合完成，由美国国家糖尿病、消化和肾脏疾病研究所(NIDDK)资助，题为“棕色脂肪组织的非侵入性测量”，并将包括用于存储至少24小时BAT测量活动的微型设备。可穿戴式连续BAT激活监测仪的可获得性不仅在开发能够激活BAT而不会引起不可接受的副作用的药物方面具有重要价值，而且在回答以下类型的重要问题方面也具有重要价值：由于暴露在寒冷中，BAT的激活时间和激活程度作为暴露时间和温度的函数而持续多久？肾上腺素能β-受体阻滞剂引起的BAT失活持续多长时间和程度与剂量有关？是否有其他广泛使用的药物可以使BAT失活？运动、饮食、吸烟、饮酒、咖啡因的摄入、寒冷天气下的衣着类型等对蝙蝠的活动有多大影响？对于任何可以增强BAT代谢活性的安全药物，这种激活持续多长时间，特定个人需要服用多少此类药物才能显著提高BAT的代谢活性？