Wearable Monitor for Recording the Activity of Brown Adipose Tissue

用于记录棕色脂肪组织活动的可穿戴监视器

• 批准号: 8779862
• 负责人: FRED STERZER
• 金额: $ 14.99万
• 依托单位: MMTC, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779862
• 关键词: Adrenergic beta-Antagonists; Adult; Adverse effects; Affect; Alcohol consumption; Authorization documentation; Brown Fat; Burn injury; Caffeine; Calories; Cause of Death; Child; Clothing; Data Storage and Retrieval; Desire for food; Development; Devices; Diabetes Mellitus; Digestive System Disorders; Drug usage; Elements; Energy Metabolism; Equipment; Exploratory/Developmental Grant; Exposure to; Fatty acid glycerol esters; Funding; Goals; Hour; Human Volunteers; Individual; Institutes; Institutional Review Boards; Joints; Kidney Diseases; Measurement; Measures; Medical; Memory; Metabolic; Methods; Modeling; Monitor; Noise; Obesity; Pharmaceutical Preparations; Phase; Positron-Emission Tomography; Prevalence; Procedures; Process; Protocols documentation; Public Health; Relative (related person); Reporting; Scanning; Simulate; Site; Skin; Small Business Innovation Research Grant; Smoking; Temperature; Testing; Time; Tissues; Universities; Variant; Vertebral column; Weather; combat; design; diet and exercise; digital; dosage; drug development; fighting; improved; instrument; instrumentation; microwave electromagnetic radiation; miniaturize; operation; programs; prototype; public health relevance

DESCRIPTION (provided by applicant): Brown Adipose Tissues (BAT) are tissues that when activated become metabolically active and take calories from normal white fat and burn them. Safe methods for creating and activating (BAT) would therefore be of great value in fighting obesity, a leading preventable cause of death with increasing prevalence in adults and children and one of the most serious public health problems of the 21st century. Current efforts to develop BAT stimulation paradigms are hindered by the inability to continuously monitor the activity of BAT with available medical scans. Positron Emission Tomography (PET) scans and other similar types of scanners that can detect activated BAT use large, expensive equipment and are only useful for providing single snapshots in time of the existence of activated BAT. The proposed Phase I SBIR program is for the development of monitors that can safely, noninvasively, and continuously record the activity of BAT of an individual over a period of at least 24 hours and that can be worn by the individuals while carrying out their normal activities. The wearable BAT monitors will be miniaturized and improved versions of the large instruments that were successfully used (P<0.01) to detect activated BAT by measuring the microwave thermal noise emitted by activated BAT in a recently completed joint Johns Hopkins University/MMTC R21 program funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) entitled "Non-Invasive Measurements of Brown Adipose Tissues", and will include miniaturized devices for storing the measured activity of BAT for periods of at least 24 hours. The availability of wearable continuous BAT activation monitors would be of great value not only in the development of drugs that can activate BAT without causing unacceptable side effects, the first obesity drugs that would affect energy expenditure rather than appetite, but also in answering the following types of important questions: How long do activations and degree of activations of BAT due to exposure to cold last as functions of durations of exposures and temperatures? How long and how deep do deactivations of BAT due to adrenergic beta-blockers last as functions of dosages and are there other widely used drugs that deactivate BAT? To what extend do exercise, diet, smoking, consumption of alcohol, caffeine, type of clothing in cold weather, etc., affect the activity of BAT? For any safe drugs tht can enhance the metabolic activity of BAT, how long does this activation last, how much of such drugs does a particular individual have to take to get a significant increase in the metabolic activity of BAT?

描述（由申请人提供）：棕色脂肪组织（BAT）是一种被激活时具有代谢活性的组织，可以从正常的白色脂肪中摄取卡路里并燃烧它们。因此，创造和激活（BAT）的安全方法在对抗肥胖方面具有重要价值。肥胖是导致死亡的主要可预防原因，在成人和儿童中日益普遍，也是21世纪最严重的公共卫生问题之一。由于现有医学扫描无法持续监测BAT的活动，目前开发BAT刺激范例的努力受到阻碍。正电子发射断层扫描（PET）扫描和其他类似类型的扫描仪可以检测活化的BAT使用大型，昂贵的设备，并且仅用于提供激活BAT存在时的单一快照。拟议的第一阶段SBIR计划是为了开发一种监测器，这种监测器可以安全、无创、连续记录个人至少24小时的BAT活动，并且可以在个人进行正常活动时佩戴。可穿戴式BAT监测仪将是大型仪器的小型化和改进版本，该大型仪器在最近完成的由美国国家糖尿病、消化和肾脏疾病研究所（NIDDK）资助的约翰霍普金斯大学/MMTC R21联合项目中，通过测量活化BAT发出的微波热噪声，成功地检测了活化BAT （P<0.01）。并将包括用于将BAT的测量活性储存至少24小时的小型化装置。可穿戴式BAT连续激活监测器的可用性不仅在开发能够激活BAT而不会产生不可接受的副作用的药物方面具有重要价值，而且在第一批影响能量消耗而不是食欲的减肥药方面具有重要价值，而且在回答以下类型的重要问题方面具有重要价值：暴露在寒冷中的BAT的激活和激活程度作为暴露时间和温度的函数持续多长时间？肾上腺素能阻滞剂引起的BAT的失活持续的时间和深度，是否有其他广泛使用的药物使BAT失活？运动、饮食、吸烟、饮酒、咖啡因的摄入、寒冷天气的服装类型等在多大程度上影响BAT的活动？对于任何可以增强BAT代谢活性的安全药物，这种激活持续多长时间，特定个体需要服用多少此类药物才能显著提高BAT的代谢活性？