PILOT PROJECT-- AWARENESS AND DENIAL

试点项目——意识与否认

• 批准号: 6295462
• 负责人: Kathleen Anne Smyth
• 金额: $ 10.24万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6295462
• 关键词: Alzheimer's disease; awareness; behavioral /social science research tag; caregivers; functional ability; human subject; neuropsychological tests; psychological defense mechanism

Whether and to what extent persons with Alzheimer's disease (AD) are aware of or deny their deficits has important implications for their diagnosis, treatment, management, and mood. As a result, deficit awareness and denial have considerable influence on family members' and professionals' communication with persons with AD, and exerts a major impact on care requirements. The theoretical significance of the study of these phenomena lies in aiding the development of a neuropsychological approach to understanding the brain systems and neural mechanisms involved in awareness and denial. Despite their clinical and theoretical significance, awareness and denial in AD have received little systematic study. Limitations of previous studies of awareness and denial include failure to distinguish the two phenomena conceptually; assessment of only a single domain of deficit; measuring multiple domains of deficit but combining the results into a single scale; relying solely on informant report as the gold standard for assessing unawareness or denial in the impaired individual; and paying limited attention to the correlates of awareness and denial. This research is designed to carefully describe awareness and denial among persons with AD, characterizing variations by domain of deficit across persons with AD and measuring awareness in multiple ways. A scale, developed in the first year of this pilot, and covering multiple domains of deficit consistent with a diagnosis of AD, will be administered 60 pairs of persons with AD and their caregivers. Pairs also will be asked to predict their own and each other's performance prior to specific neuropsychological tests and then to rate their performance after the tests have been taken. Determining correlates of awareness and denial among AD patients will contribute to understanding of the neuropsychological basis of these phenomena. Assessment will include the relationship between awareness of and denial of deficits and dementia severity, activities of daily living, depression, hallucinations, and delusions; and objective assessment of memory functions, language abilities, and visuospatial capacities, and executive functions. In addition, the relationship between awareness and denial in persons with AD and the emotional health of their caregivers will be explored.

是否以及在何种程度上患有阿尔茨海默氏病（AD）的人 意识或否认他们的缺陷对他们的赤字具有重要的影响 诊断，治疗，管理和情绪。 结果，赤字 意识和否认对家庭成员和 专业人士与广告人的沟通，并发挥主要作用 对护理要求的影响。 研究的理论意义 这些现象在于有助于神经心理学的发展 理解大脑系统和神经机制的方法 参与意识和否认。 尽管它们的临床意义和理论意义，意识和否认 在广告中，几乎没有系统的研究。 以前的局限性 意识和否认的研究包括未能区分这两个 从概念上讲现象；仅评估一个赤字领域； 测量赤字的多个领域，但将结果结合到一个 单尺度；仅依靠线人报告作为黄金标准 评估受损的人的意识或否认；和付款 对意识和否认相关的关注有限。 这项研究旨在仔细描述意识和否认 在AD的人中，表征赤字领域的变化 跨广告的人，并以多种方式衡量意识。 一个 比例，在该飞行员的第一年开发，并覆盖多个 与AD诊断一致的赤字域将是 管理60对AD及其护理人员的人。 成对 还将被要求预测自己和彼此的表现 在进行特定的神经心理学测试之前，然后对其进行评分 测试后的性能。 确定广告患者的意识和否认相关性 有助于理解这些神经心理学基础 现象。 评估将包括意识之间的关系 否认赤字和痴呆症的严重程度，日常生活的活动， 抑郁，幻觉和妄想；和客观评估 记忆功能，语言能力和视觉空间能力，以及 执行职能。 此外，意识与 拒绝广告的人及其护理人员的情感健康 将被探索。