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DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9

DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9
氟比洛芬作为 CYP2C9 选择性探针的开发
批准号：
6219233
负责人：
ROBERT A BRANCH
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219233
关键词：
analgesics clinical research cytochrome P450 drug metabolism human subject pathologic process prognosis

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中文摘要
翻译
药物代谢是体内重要的代谢过程，参与药物的清除和某些化合物的活化，从而产生毒性。 本项目旨在研究氟比洛芬作为CYP2C9选择性探针的潜在用途，以及将其掺入已开发的5种药物鸡尾酒中的可能性。目的是能够在大规模人群研究中使用它来评估CYP2C9在疾病发病机制或预后中的作用。
英文摘要
Drug metabolism is an important process in the body involved in drug elimination as well as in activation of some compounds & the consequential development of toxicities. This project is designed to investigate the potential use of Flubiprofen as a selective probe of CYP2C9 & the possibility of incorporating it into an already developed 5 drug cocktail. The objective is to be able to use it in large population studies to assess the role of CYP2C9 in the pathogenesis or prognosis of diseases.
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