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DOES QUININE HAVE ANALGESIC EFFECTS--STUDY OF PATIENT WITH LOW BACK PAIN

DOES QUININE HAVE ANALGESIC EFFECTS--STUDY OF PATIENT WITH LOW BACK PAIN
奎宁有镇痛作用吗--腰痛患者的研究
批准号：
6219272
负责人：
ROBERT A BRANCH
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219272
关键词：
analgesics backache clinical research clinical trials drug metabolism drug screening /evaluation human subject human therapy evaluation leg quinine

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中文摘要
翻译
在标准药理学教科书中已经指出奎宁具有镇痛作用，但这种说法的有效性尚不确定。 奎宁作为镇痛剂的潜在作用将在慢性腰腿疼痛患者的这项研究中进行评估。 本试验还将评价奎宁代谢与其缓解疼痛特性之间的关系。 将比较患者服用安慰剂时的疼痛强度（使用视觉模拟量表），并与患者接受奎宁时的评分进行比较。
英文摘要
It has been stated in standard pharmacologic text books that quinine has analgesic effects, but the validity of this statement is uncertain. The potential role of quinine as an analgesic agent will be assessed in this study of patients with chronic low back and leg pain. The relationship between quinine metabolism and its pain relieving properties will also be evaluated in this trial. Pain intensity will be compared (using a visual analogue scale) while the patient is taking a placebo and compared to scores when the patient is receiving quinine.
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