GANCICLOVIR-CIDOFOVIR CYTOMEGALOVIRUS (CMV) RETINITIS TRIAL--AIDS

更昔洛韦-西多福韦巨细胞病毒 (CMV) 视网膜炎试验 - 艾滋病

• 批准号: 6122151
• 负责人: BRUCE A BARRON
• 金额: $ 1.12万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-19 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122151
• 关键词: AIDS; antiviral agents; clinical research; clinical trial phase I; combination chemotherapy; cytomegalovirus; dosage forms; eye disorder chemotherapy; ganciclovir; human subject; human therapy evaluation; opportunistic infections; retinitis

People with AIDS often get an eye infection caused by cytomegalovirus (CMV). The infection involves the retina and can cause loss of vision. However, treatment can help prevent loss of vision. The purpose of this study is to compare two treatments for CMV retinitis: 1) ganciclovir ocular implant plus ganciclovir given orally and 2) cidofovir injections. Although both drugs are approved by the FDA, this study is being done to answer questions as to which form of treatment is the best.

患有艾滋病的人经常会受到由巨细胞病毒（CMV）引起的眼部感染。 感染涉及视网膜，可导致视力丧失。然而，治疗可以帮助防止视力丧失。 本研究的目的是比较两种治疗CMV视网膜炎的方法：1）更昔洛韦眼植入剂+口服更昔洛韦和2）西多福韦注射剂。虽然这两种药物都得到了FDA的批准，但这项研究是为了回答哪种治疗形式是最好的问题。