LONGITUDINAL STUDY OF THE OCULAR COMPLICATIONS OF AIDS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Longitudinal Study of the Ocular Complications of AIDS (LSOCA) is a multicenter, prospective, observational study of patients with AIDS. Patients with a diagnosis of AIDS according to the 1993 CDC criteria, with or without ocular complications, will be enrolled over a four year period. The objectives of this study are: 1) to monitor secular trends in the incidence of the ocular complication of AIDS; 2) to determine the effect of HAART-induced changes in immune status on the incidence and course of the ocular complications of AIDS; 3) to determine the characteristics of patients that place them at high risk for ocular complications; 4) to evaluate the effects of treatments of CMV retinitis and other ocular complications on visual function, quality of life, and survival. Other outcomes of interest include incidence of extra-ocular CMV disease, sequelae of AIDS-related eye disease, visual function, quality of life, and incidence of complications of therapies for ocular complications.