LONGITUDINAL STUDY OF THE OCULAR COMPLICATIONS OF AIDS

艾滋病眼部并发症的纵向研究

• 批准号: 7376244
• 负责人: BRUCE A BARRON
• 金额: $ 35.86万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376244
• 关键词: LONGITUDINAL; STUDY; OCULAR; COMPLICATIONS; AIDS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Longitudinal Study of the Ocular Complications of AIDS (LSOCA) is a multicenter, prospective, observational study of patients with AIDS. Patients with a diagnosis of AIDS according to the 1993 CDC criteria, with or without ocular complications, will be enrolled over a four year period. The objectives of this study are: 1) to monitor secular trends in the incidence of the ocular complication of AIDS; 2) to determine the effect of HAART-induced changes in immune status on the incidence and course of the ocular complications of AIDS; 3) to determine the characteristics of patients that place them at high risk for ocular complications; 4) to evaluate the effects of treatments of CMV retinitis and other ocular complications on visual function, quality of life, and survival. Other outcomes of interest include incidence of extra-ocular CMV disease, sequelae of AIDS-related eye disease, visual function, quality of life, and incidence of complications of therapies for ocular complications.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。艾滋病眼部并发症的纵向研究（LSOCA）是一项针对艾滋病患者的多中心、前瞻性、观察性研究。根据1993年疾病预防控制中心标准诊断为艾滋病的患者，不论有无眼部并发症，将在四年期间登记。本研究的目的是：1)监测艾滋病眼部并发症发生率的长期趋势；2)确定haart诱导的免疫状态变化对艾滋病眼部并发症发生率和病程的影响；3)确定眼部并发症高危患者的特征；4)评价巨细胞病毒性视网膜炎及其他眼部并发症的治疗对视功能、生活质量和生存的影响。其他值得关注的结局包括眼外巨细胞病毒疾病的发生率、艾滋病相关眼病的后遗症、视觉功能、生活质量和眼部并发症治疗的并发症发生率。